Product image of Mirtazapine Arrow (Mirtazapine) supplied by GNH India

Mirtazapine Arrow

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine Arrow (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapine Arrow, is a Noradrenergic and specific serotonergic antidepressant (NaSSA) presented as an oral dosage form for oral use. It is prescribed for the treatment of major depressive disorder in adult patients.

GNH India supplies Mirtazapine Arrow as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Arrow Generiques

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Indications & Clinical Uses

Mirtazapine is a NaSSA antidepressant used primarily in the management of depressive disorders.

  • Major depressive disorder: alleviates depressive symptoms, improves mood, sleep and appetite.

How It Works

  • Mirtazapine acts by antagonising central presynaptic α2‑adrenergic receptors, which increases norepinephrine and serotonin release. It also blocks 5‑HT2 and 5‑HT3 receptors and exhibits potent H1‑histamine receptor antagonism, contributing to its antidepressant and sedative properties.

Side Effects

Mirtazapine may cause a range of adverse reactions, from frequent to rare.

Common Side Effects

  • Sedation: drowsiness, especially at treatment initiation.
  • Increased appetite: may lead to weight gain.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.
  • Dizziness: light‑headedness on standing.
  • Fatigue: general lack of energy.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Stevens‑Johnson syndrome: serious skin reaction.
  • Hepatic dysfunction: elevated liver enzymes.
  • Suicidal thoughts: emergence or worsening of suicidal ideation.
  • Severe hypotension: marked drop in blood pressure.
  • Neuroleptic malignant‑like syndrome: rare but life‑threatening condition.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Pregnancy: Category C; evaluate risk‑benefit ratio with prescriber.
  • Elderly patients: monitor for excessive sedation and fall risk.
  • Hepatic impairment: dose adjustment may be required.
  • Concomitant CNS depressants: may enhance sedative effects.
  • Suicidal ideation: close monitoring during early treatment.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Linezolid or other reversible MAO‑A inhibitors: potential serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs): increased serotonin syndrome risk.

Moderate Interactions (Monitor Closely)

  • CNS depressants (benzodiazepines, alcohol): enhanced sedation.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may raise mirtazapine levels.
  • Antihistamines: additive anticholinergic effects.
  • Diuretics: possible additive hypotensive effect.

Frequently Asked Questions

Mirtazapine Arrow contains the active ingredient mirtazapine, which is indicated for the treatment of major depressive disorder in adult patients. It helps improve mood, sleep quality, and appetite by modulating neurotransmitter activity in the brain.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, leading to increased release of norepinephrine and serotonin. It also antagonises 5‑HT2, 5‑HT3 and H1‑histamine receptors, which together produce antidepressant and sedative effects.

The appropriate dose of Mirtazapine Arrow is determined by the prescribing clinician based on the patient’s clinical condition, response to therapy, and any relevant medical factors. Dosage adjustments are made according to individual needs.

Mirtazapine is classified as Pregnancy Category C, meaning risk cannot be ruled out. It should only be used during pregnancy or lactation if the potential benefit justifies the potential risk, and this decision must be made by a qualified healthcare professional.

To order Mirtazapine Arrow, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct mechanism involving α2‑adrenergic antagonism and strong antihistamine activity, which often results in greater sedation and weight gain. It may be preferred when insomnia or loss of appetite are prominent symptoms.

Mirtazapine Arrow should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperatures to maintain its stability and potency.

Mirtazapine Arrow is taken orally, usually once daily in the evening due to its sedative effect. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include the potential for agranulocytosis, severe hepatic dysfunction, Stevens‑Johnson syndrome, and the emergence or worsening of suicidal thoughts, especially during the early phase of treatment. Prompt medical attention is required if any of these occur.

Mirtazapine Arrow should be avoided in patients with known hypersensitivity to mirtazapine or any of its excipients, and in individuals currently taking monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing an MAOI. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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