Product image of Mirtazapine Eg (Mirtazapine) supplied by GNH India

Mirtazapine Eg

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine Eg (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapine Eg, is a tetracyclic antidepressant presented as an oral tablet for oral use. It treats major depressive disorder in adults.\n\nGNH India supplies Mirtazapine Eg as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Eurogenerics N.V./S.A.

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Indications & Clinical Uses

  • Mirtazapine is a tetracyclic antidepressant indicated for depressive disorders.\n\nMajor depressive disorder: reduces depressive symptoms and improves mood in adult patients.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, enhancing norepinephrine release, and blocks serotonin 5‑HT2 and 5‑HT3 receptors, which increases serotonergic transmission while minimizing certain side effects. This combined action elevates both norepinephrine and serotonin levels in the CNS, contributing to its antidepressant effect.

Side Effects

  • Mirtazapine may cause a range of adverse reactions.\n\nCommon Side Effects:\n- Sedation: drowsiness or sleepiness, especially at treatment start.\n- Increased appetite and weight gain: notable rise in food intake and body weight.\n- Dry mouth: reduced salivation leading to discomfort.\n- Constipation: slowed gastrointestinal transit.\n\nSerious or Rare Side Effects:\n- Agranulocytosis or severe neutropenia: markedly reduced white‑blood‑cell count.\n- Hepatic dysfunction: elevated liver enzymes or hepatitis.\n- Suicidal thoughts or behavior: emergence of suicidal ideation, particularly early in therapy.

Precautions & Warnings

  • Before initiating therapy, several safety considerations are recommended.\n\nMonitor weight: track changes due to increased appetite.\nAssess for suicidal ideation: especially during the first weeks of treatment.\nUse caution in hepatic impairment: adjust dose if liver function is compromised.\nAvoid abrupt discontinuation: taper under medical supervision to reduce withdrawal effects.\nReview concomitant CNS depressants: risk of enhanced sedation.\nStore at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

  • Mirtazapine can interact with other medicines, requiring careful management.\n\nMajor Interactions (Avoid):\n- MAO inhibitors: risk of hypertensive crisis.\n- Other serotonergic agents: potential serotonin syndrome.\n- CNS depressants: additive sedation.\n- Strong CYP2D6 inhibitors: increased mirtazapine plasma levels.\n\nModerate Interactions (Monitor Closely):\n- Alcohol: may enhance central nervous system depression.\n- Antihypertensives: possible additive blood‑pressure lowering effect.\n- Anticholinergic drugs: may worsen dry mouth and constipation.\n- Carbamazepine: may reduce mirtazapine concentrations.\n- Warfarin: occasional alteration of INR, requiring monitoring.

Frequently Asked Questions

Mirtazapine Eg is used to treat major depressive disorder in adult patients. It belongs to the tetracyclic antidepressant class and helps alleviate depressive symptoms such as low mood, loss of interest, and impaired concentration.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine, and by antagonising serotonin 5‑HT2 and 5‑HT3 receptors. This dual action raises overall serotonin and norepinephrine activity in the brain, producing an antidepressant effect.

The dose of Mirtazapine Eg is individualized by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. The prescriber determines the appropriate starting dose and any subsequent adjustments.

Safety data for Mirtazapine during pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made in consultation with a qualified healthcare professional.

To order Mirtazapine Eg, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine often produces more sedation and weight gain but may be better tolerated in patients who experience sexual dysfunction or gastrointestinal side effects with SSRIs. Both classes are effective for depression, and choice depends on individual patient factors.

Mirtazapine Eg should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date.

Mirtazapine Eg is administered orally, usually once daily in the evening because of its sedative effect. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber.

Serious risks include agranulocytosis or severe neutropenia, hepatic dysfunction, and the emergence of suicidal thoughts or behaviors, especially during the initial weeks of therapy. Patients should seek immediate medical attention if they notice signs of infection, jaundice, or worsening mood.

Mirtazapine Eg should not be used by individuals with known hypersensitivity to the drug, those currently taking monoamine oxidase inhibitors, or patients with severe hepatic impairment. Contraindications and precautions must be reviewed by a healthcare professional before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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