Mirtazapine Manx Healthcare (Mirtazapine)

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases the release of norepinephrine and serotonin. It also antagonises specific serotonin receptors (5‑HT2 and 5‑HT3) and histamine H1 receptors, enhancing serotonergic activity while providing sedative and appetite‑stimulating effects that contribute to its antidepressant action.

The dose of mirtazapine is individualized by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Typical starting doses may be low and are adjusted as needed, but exact dosing regimens should always follow the prescriber’s written instructions.

Safety data for mirtazapine during pregnancy and lactation are limited. The potential benefits must be weighed against possible risks to the fetus or infant. Healthcare providers should discuss the risk‑benefit profile with the patient and consider alternative therapies when appropriate.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and specific serotonin receptors, as well as strong H1 antagonism. This profile often results in pronounced sedation and appetite stimulation, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those who need an activating effect.

Store the product at ambient temperature, preferably below 25 °C. Keep it in the original packaging to protect from moisture and light. Do not refrigerate or freeze the tablets, and keep them out of reach of children.

Mirtazapine is taken orally, usually once daily in the evening. Tablets should be swallowed whole with a glass of water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious adverse events, although rare, include agranulocytosis (dangerously low white‑blood‑cell count), seizures, and severe hypersensitivity reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience signs of infection, convulsions, or any severe allergic response.

Mirtazapine is contraindicated in patients currently taking monoamine oxidase inhibitors (MAOIs) or those with known hypersensitivity to the drug. Caution is advised in individuals with severe hepatic impairment, uncontrolled epilepsy, or a history of severe blood dyscrasias. The prescriber should evaluate each patient’s medical history before initiating therapy.