Product image of Mirtazapine Mylan (Mirtazapine) supplied by GNH India

Mirtazapine Mylan

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine Mylan (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapine Mylan, is an antidepressant presented as an oral tablet for oral use. It works by modulating neurotransmitter activity and is indicated for the treatment of major depressive disorder in adult patients, helping to improve mood, sleep and appetite. The medication is used under medical supervision to address depressive symptoms and associated functional impairment.

GNH India supplies Mirtazapine Mylan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Generics [uk] Limited

1
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Indications & Clinical Uses

  • Mirtazapine is an antidepressant that acts on serotonergic and noradrenergic pathways to treat depressive disorders.
  • Major depressive disorder: reduces depressive symptoms and improves overall mood.
  • Depressive episodes with prominent anxiety: alleviates both mood and anxiety components.
  • Adjunctive therapy for treatment‑resistant depression: may enhance response when combined with other antidepressants.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, which enhances serotonergic transmission while reducing serotonergic side‑effects. This combined action raises synaptic concentrations of norepinephrine and serotonin, contributing to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation

Serious or Rare Side Effects

  • Severe neutropenia or agranulocytosis
  • Elevated liver enzymes indicating hepatic injury
  • Suicidal thoughts or behavior, especially early in treatment

Precautions & Warnings

  • Before prescribing mirtazapine, clinicians should consider several safety aspects.
  • Assess psychiatric history: evaluate risk of suicidal ideation before initiating therapy.
  • Monitor weight and metabolic parameters: watch for significant weight gain.
  • Check liver function: consider baseline and periodic tests.
  • Use caution in elderly: increased sensitivity to sedation and falls.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis; a washout period is required.
  • CNS depressants (e.g., benzodiazepines, alcohol): may intensify sedation.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): can increase mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers (e.g., carbamazepine, rifampin): may reduce effectiveness.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): monitor for serotonin syndrome.
  • Anticholinergic drugs: additive dry mouth and constipation.

Frequently Asked Questions

Mirtazapine Mylan is a prescription antidepressant indicated for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms such as low mood, loss of interest, sleep disturbances, and appetite changes.

Mirtazapine works by blocking central presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing 5‑HT2 and 5‑HT3 serotonin receptors. This dual action raises levels of norepinephrine and serotonin in the brain, contributing to its antidepressant effect.

The appropriate dose of Mirtazapine Mylan is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of mirtazapine in pregnancy and lactation has not been definitively established. Healthcare providers weigh potential benefits against possible risks before prescribing it to pregnant or nursing women, and alternative treatments may be considered.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine differs from many selective serotonin reuptake inhibitors (SSRIs) by also enhancing norepinephrine release and by its antagonism of certain serotonin receptors, which can lead to a distinct side‑effect profile such as increased appetite and sedation. Choice of therapy depends on patient‑specific factors and clinician judgment.

Mirtazapine Mylan tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Mirtazapine Mylan is taken orally, usually once daily in the evening with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush or chew unless specifically instructed.

Serious risks include the potential for severe neutropenia or agranulocytosis, significant liver enzyme elevations indicating hepatic injury, and the emergence or worsening of suicidal thoughts, particularly early in treatment or when dose changes occur.

Mirtazapine is contraindicated in patients who have taken a monoamine oxidase inhibitor (MAOI) within the past 14 days, or in individuals with known hypersensitivity to mirtazapine or any of its excipients. Caution is also advised for patients with severe hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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