Product image of Mirtazapine Teva (Mirtazapine) supplied by GNH India

Mirtazapine Teva

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine Teva (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapine Teva, is a tetracyclic antidepressant presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients, helping to improve mood and functional outcomes. It is available in dosage strengths that allow flexible titration according to clinical response.

GNH India supplies Mirtazapine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and procurement teams worldwide, ensuring quality‑assured products that meet regulatory standards across diverse markets.

Manufacturer / TM Owner

Teva Santé

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Indications & Clinical Uses

Mirtazapine is a tetracyclic antidepressant used in the management of depressive disorders.

  • Major depressive disorder: alleviates depressive symptoms and improves overall mood and functioning.

How It Works

  • Mirtazepine blocks central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and antagonizes 5‑HT2 and 5‑HT3 serotonin receptors, which together enhance serotonergic and noradrenergic neurotransmission, contributing to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions.

Common Side Effects

  • Sedation: feeling unusually sleepy or drowsy.
  • Increased appetite: heightened desire for food, often leading to weight gain.
  • Weight gain: noticeable increase in body weight.
  • Dry mouth: reduced salivation causing oral discomfort.
  • Constipation: infrequent or difficult bowel movements.
  • Dizziness: sensation of light‑headedness or imbalance.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Severe neutropenia: markedly low neutrophil count.
  • Seizures: convulsive episodes.
  • Hypersensitivity reactions: rash, swelling, or anaphylaxis.
  • Suicidal thoughts: emergence or worsening of suicidal ideation.
  • Hepatotoxicity: potential liver injury.

Precautions & Warnings

Before prescribing Mirtazapine, clinicians should consider several safety aspects.

  • Monitor depression: watch for worsening mood or emergence of suicidal thoughts.
  • Hepatic impairment: use cautiously in patients with liver dysfunction.
  • Discontinuation: avoid abrupt stopping to reduce withdrawal risk.
  • Elderly patients: start at low dose and monitor for sedation.
  • Pregnancy and lactation: safety not established; discuss risks with a healthcare provider.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Mirtazapine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • CNS depressants (e.g., benzodiazepines, opioids): enhanced sedation and respiratory depression.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increased mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • Other antidepressants (SSRIs, SNRIs): potential for serotonin syndrome.
  • Alcohol: may intensify sedative effects.
  • Antihistamines: additive drowsiness.
  • Carbamazepine: may reduce mirtazapine effectiveness.
  • Warfarin: monitor INR for possible anticoagulant effect changes.

Frequently Asked Questions

Mirtazapine Teva is prescribed for the treatment of major depressive disorder in adult patients. It helps to relieve depressive symptoms, improve mood, and enhance overall functional capacity as part of a comprehensive psychiatric care plan.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing 5‑HT2 and 5‑HT3 serotonin receptors. These actions raise the levels of norepinephrine and serotonin in the brain, contributing to its antidepressant effect.

The appropriate dose of Mirtazapine Teva is determined by the prescribing clinician based on the individual’s clinical condition, response to therapy, and tolerability. Patients should follow the dosage instructions provided by their healthcare professional.

Safety of Mirtazapine Teva in pregnancy and lactation has not been definitively established. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their physician before using this medication.

To order Mirtazapine Teva, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine differs from selective serotonin reuptake inhibitors (SSRIs) by its dual action on norepinephrine and serotonin pathways and its antihistaminic properties, which often cause sedation and weight gain. It may be preferred when patients experience insomnia or need an alternative to SSRIs, but individual response varies.

Mirtazapine Teva should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Mirtazapine Teva is taken orally, usually as a tablet. The tablet should be swallowed whole with water, preferably in the evening due to its sedative effect, unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe neutropenia, seizures, hypersensitivity reactions such as rash or anaphylaxis, and the possible emergence or worsening of suicidal thoughts. Patients should seek immediate medical attention if they experience any of these severe symptoms.

Mirtazapine Teva is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients, and in those currently taking monoamine oxidase inhibitors (MAOIs). Caution is also advised for individuals with severe hepatic impairment, uncontrolled epilepsy, or a history of suicidal behavior.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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