Product image of Mirtazapine Teva (Mirtazapine) supplied by GNH India

Mirtazapine Teva

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine Teva (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapine Teva, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It treats major depressive disorder in adult patients.
GNH India supplies Mirtazapine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Mirtazapine is indicated for the treatment of major depressive disorder, a mood disorder characterized by persistent low mood and loss of interest.

  • Major depressive disorder: alleviates depressive symptoms and improves mood in adults.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission. Its potent H1 histamine receptor antagonism contributes to sedation and appetite stimulation, collectively improving depressive symptoms.

Side Effects

Mirtazapine may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Sedation: drowsiness, especially after initial doses.
  • Increased appetite: often leading to weight gain.
  • Dry mouth: reduced salivation.
  • Constipation: slowed gastrointestinal motility.

Serious or Rare Side Effects

  • Agranulocytosis: severe reduction in white blood cells.
  • Hepatic dysfunction: abnormal liver enzymes.
  • Severe hypersensitivity: rash, swelling, or anaphylaxis.
  • Suicidal thoughts: emergence or worsening of suicidal ideation.

Precautions & Warnings

Before prescribing Mirtazapine, clinicians should consider several safety factors.

  • Assess hepatic function: adjust use in severe liver impairment.
  • Monitor weight: patients may experience significant weight gain.
  • Screen for suicidal ideation: especially during treatment initiation.
  • Caution in elderly: increased risk of sedation and falls.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Store at ambient temperature: keep in original container, protect from moisture.

Avoid Interactions

Mirtazapine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Strong CYP2D6 inhibitors: may raise plasma mirtazapine levels.
  • CNS depressants: additive sedation and respiratory depression.

Moderate Interactions (Monitor Closely)

  • Other antidepressants: potential for serotonin syndrome.
  • Antihistamines: may enhance sedative effects.
  • Alcohol: increases central nervous system depression.

Frequently Asked Questions

Mirtazapine Teva is used to treat major depressive disorder in adult patients. It belongs to the NaSSA class of antidepressants and helps improve mood, sleep, and appetite by modulating norepinephrine and serotonin pathways.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and antagonizes postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic activity. Its strong H1 histamine antagonism also contributes to sedation and appetite stimulation.

The appropriate dose of Mirtazapine Teva is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions.

Safety data for mirtazapine in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct receptor profile that often results in greater sedation and appetite stimulation, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those concerned about weight gain.

Mirtazapine Teva tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use after the expiry date.

Mirtazapine Teva is taken orally, usually once daily in the evening due to its sedative effect. The tablet should be swallowed whole with water and not crushed or chewed unless otherwise directed by a healthcare professional.

Serious risks include agranulocytosis, severe hepatic dysfunction, and the emergence or worsening of suicidal thoughts, especially during the early phase of treatment. Patients should be monitored closely for any signs of infection, liver issues, or changes in mood.

Mirtazapine should be avoided in patients who have taken monoamine oxidase inhibitors within the past 14 days, those with known hypersensitivity to the drug, or individuals with severe hepatic impairment without appropriate dose adjustment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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