Product image of Mirtazapine Teva (Mirtazapine) supplied by GNH India

Mirtazapine Teva

Active Ingredient:
Mirtazapine
Origin:
EU

Mirtazapine Teva (Mirtazapine)

Mirtazapine, the active ingredient in Mirtazapine Teva, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It is prescribed for the treatment of major depressive disorder in adult patients.
GNH India supplies Mirtazapine Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Nederland B.V.

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Indications & Clinical Uses

Mirtazapine Teva is a NaSSA antidepressant that acts on central neurotransmitter pathways to improve mood in depressive disorders.

  • Major depressive disorder: alleviates depressive symptoms and improves functional outcomes in adults.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and antagonizes 5‑HT2 and 5‑HT3 receptors, which enhances serotonergic transmission while reducing serotonergic side‑effects. The combined effect leads to increased noradrenergic and serotonergic activity that contributes to its antidepressant properties.

Side Effects

Mirtazapine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Seizures
  • Suicidal thoughts or behavior
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Hepatic dysfunction
  • Orthostatic hypotension

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Hepatic function: assess liver enzymes in patients with hepatic impairment.
  • Weight monitoring: track body weight due to possible increase.
  • Elderly patients: start at lower doses and monitor for sedation.
  • Discontinuation: avoid abrupt cessation to reduce withdrawal symptoms.
  • Pregnancy and lactation: consider risk‑benefit ratio; use only if clearly needed.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with several drug classes; careful review of concomitant medications is essential.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): potential serotonin syndrome.
  • Carbamazepine: induces metabolism, reducing efficacy.
  • Fluoxetine or other CYP2D6 inhibitors: may increase mirtazapine levels.
  • Alcohol: enhances sedative effects.

Moderate Interactions (Monitor Closely)

  • Antihistamines: additive sedation.
  • Benzodiazepines: increased central nervous system depression.
  • Warfarin: possible alteration of INR.
  • NSAIDs: heightened risk of gastrointestinal bleeding.
  • Antihypertensives: may potentiate blood pressure lowering.

Frequently Asked Questions

Mirtazapine Teva is a prescription‑only antidepressant indicated for the treatment of major depressive disorder in adult patients. It helps to reduce depressive symptoms, improve mood, and enhance overall functional capacity when used as part of a comprehensive treatment plan.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing 5‑HT2 and 5‑HT3 receptors. This dual action boosts both noradrenergic and serotonergic neurotransmission, leading to an overall antidepressant effect.

The dosage of Mirtazapine Teva is individualized. A qualified prescriber determines the appropriate starting dose, titration schedule, and maintenance dose based on the patient’s clinical response, tolerability, and any co‑existing medical conditions.

Safety data for Mirtazapine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), Mirtazapine often produces more sedation and weight gain but may be advantageous for patients with insomnia or poor appetite. Its distinct receptor profile can be useful when SSRIs are ineffective or poorly tolerated.

Store the tablets at room temperature, preferably below 25 °C. Keep them in the original blister pack or container, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Mirtazapine Teva is taken orally, usually once daily in the evening. Swallow the tablet whole with water; it may be taken with or without food, although taking it with food can reduce gastrointestinal discomfort.

Serious risks include agranulocytosis, severe neutropenia, seizures, suicidal thoughts or behaviors, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and significant hepatic dysfunction. Patients should be monitored closely for any of these events.

Mirtazapine is contraindicated in patients who have taken a monoamine oxidase inhibitor (MAOI) within the past 14 days, those with known hypersensitivity to mirtazapine, and individuals with severe hepatic impairment. Caution is also advised for patients with a history of bipolar disorder or uncontrolled epilepsy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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