Product image of Mirzaten (Mirtazapine) supplied by GNH India

Mirzaten

Active Ingredient:
Mirtazapine
Origin:
EU

Mirzaten (Mirtazapine)

Mirtazapine, the active ingredient in Mirzaten, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral administration. It enhances noradrenergic and serotonergic neurotransmission and is primarily prescribed for the management of major depressive disorder in adult patients who require a rapid improvement in mood and sleep quality.

GNH India supplies Mirzaten as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality, regulatory compliance and reliable logistics for global health partners.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Mirtazapine is used to treat depressive disorders by modulating noradrenergic and serotonergic pathways.
  • Major depressive disorder: reduces core depressive symptoms and improves sleep in adult patients.
  • Depressive symptoms with comorbid insomnia: helps improve sleep quality while treating depression.
  • Adjunctive therapy for treatment‑resistant depression: may be added when response to first‑line antidepressants is inadequate.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, thereby increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission. It also antagonises H1 histamine receptors, contributing to its sedative and appetite‑stimulating effects, while the combined actions result in antidepressant activity.

Side Effects

Mirtazapine may cause a range of adverse reactions that vary in frequency.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Serotonin syndrome, especially with other serotonergic agents
  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome)
  • Suicidal thoughts or worsening depression
  • Abnormal liver function tests

Precautions & Warnings

Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.

  • Psychiatric assessment: screen for suicidal ideation and worsening depression.
  • Hepatic function: adjust dose or monitor in patients with liver impairment.
  • Elderly patients: start at low dose and monitor for excessive sedation.
  • Discontinuation: taper gradually to avoid withdrawal symptoms.
  • Concomitant CNS depressants: use caution due to additive sedation.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of serotonin syndrome; discontinue MAOI at least 14 days before starting.
  • Linezolid or methylene blue: potent serotonergic activity may precipitate serotonin syndrome.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • CNS depressants (alcohol, benzodiazepines): additive sedation and respiratory depression.
  • Other serotonergic agents (SSRIs, SNRIs, tramadol): monitor for signs of serotonin syndrome.
  • Anticholinergic drugs: may exacerbate dry mouth and constipation.
  • Warfarin: occasional reports of altered INR; monitor coagulation parameters.

Frequently Asked Questions

Mirzaten contains the active ingredient mirtazapine and is prescribed to treat major depressive disorder in adult patients. It helps alleviate depressive symptoms, improve mood, and can also aid sleep quality as part of a comprehensive treatment plan.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonising 5‑HT2 and 5‑HT3 serotonin receptors. These actions boost noradrenergic and serotonergic neurotransmission, producing antidepressant effects while H1 receptor blockade contributes to sedation.

The dose of Mirzaten is individualized by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. Dosage adjustments are made according to professional guidelines and the patient’s specific needs.

Safety data for mirtazapine in pregnancy and lactation are limited. The prescriber must weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their healthcare provider.

To place an order, submit an enquiry on the Mirzaten product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct receptor profile that often results in stronger sedative and appetite‑stimulating effects. It may be preferred when patients need help with insomnia or weight gain, while SSRIs are generally less sedating.

Mirzaten should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability and potency throughout its shelf life.

Mirzaten is taken orally, usually once daily in the evening due to its sedative properties. The tablet should be swallowed whole with water and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious risks include the potential for agranulocytosis or severe neutropenia, serotonin syndrome when combined with other serotonergic drugs, and worsening depression or emergence of suicidal thoughts, especially during early treatment or dose changes.

Mirzaten is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients. It should also be avoided in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those with a history of severe agranulocytosis.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Related Products

Other formulations containing Mirtazapine

A

A
A

A
A

A
A

A

Browse all products →

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Regulatory recognitions

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.

SGS GSDP Certification

GSDP Compliant from SGS

URS ISO 9001

URS ISO 9001 Certification

FDA Maharashtra

Licensed by FDA Maharashtra

IEC License DGFT

IEC License issued by DGFT