Product image of Mirzaten (Mirtazapine) supplied by GNH India

Mirzaten

Active Ingredient:
Mirtazapine
Origin:
EU

Mirzaten (Mirtazapine)

Mirtazapine, the active ingredient in Mirzaten, is a NaSSA presented as a tablet for oral use. It treats major depressive disorder in adults.
GNH India supplies Mirzaten as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Mirtazapine is indicated for major depressive disorder, a condition involving dysregulated serotonergic and noradrenergic pathways.
  • Major depressive disorder: reduces depressive symptoms and improves overall mood.
  • Depressive symptoms in chronic illness: helps alleviate mood disturbances associated with long‑term disease.
  • Adjunct therapy for treatment‑resistant depression: may be added when first‑line agents are insufficient.

How It Works

  • Mirtazapine acts as an antagonist at central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, thereby enhancing serotonergic transmission while reducing serotonergic side‑effects. This combined noradrenergic and serotonergic potentiation underlies its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or neutropenia
  • Severe hypersensitivity reactions (rash, angioedema)
  • Suicidal thoughts, especially early in therapy
  • Serotonin syndrome when combined with other serotonergic agents
  • Hepatotoxicity (rare liver enzyme elevations)

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Hepatic function: assess liver status, adjust if severe impairment.
  • Weight monitoring: counsel patients about potential weight gain.
  • Elderly patients: start at low dose due to increased sedation risk.
  • Discontinuation: avoid abrupt stop to reduce withdrawal symptoms.
  • Bipolar disorder: monitor for emergence of mania.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis and serotonin syndrome.
  • Other serotonergic agents (SSRIs, SNRIs, tramadol): increase serotonin syndrome risk.
  • CNS depressants (benzodiazepines, alcohol): additive sedation and respiratory depression.
  • CYP2D6 inhibitors (paroxetine, fluoxetine): may raise mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: potential additive hypotensive effect.
  • Anticholinergic drugs: may exacerbate dry mouth and constipation.
  • Carbamazepine: may reduce mirtazapine concentrations, lowering efficacy.

Frequently Asked Questions

Mirzaten contains the active ingredient mirtazapine and is prescribed for the treatment of major depressive disorder in adult patients. It helps alleviate depressive symptoms, improve mood, and can also aid sleep disturbances associated with depression.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing 5‑HT2 and 5‑HT3 receptors. This dual action enhances serotonergic and noradrenergic neurotransmission, contributing to its antidepressant effect.

The dosage of Mirzaten is individualized by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. The prescriber determines the appropriate starting dose and any subsequent adjustments.

The safety of mirtazapine in pregnancy and lactation has not been definitively established. It is classified as pregnancy category unknown, and clinicians should weigh potential benefits against possible risks before prescribing to pregnant or nursing women.

To order Mirzaten, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct mechanism that often results in higher sedation and appetite stimulation, which can be advantageous for patients with insomnia or weight loss. However, SSRIs may have a lower risk of weight gain.

Mirzaten should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the packaging remains tightly closed.

Mirzaten is taken orally, usually once daily in the evening due to its sedative effect. Patients should swallow the tablet whole with water and follow the dosing schedule prescribed by their healthcare professional.

Serious risks include agranulocytosis or neutropenia, severe hypersensitivity reactions, emergence of suicidal thoughts especially early in treatment, and serotonin syndrome when combined with other serotonergic drugs. Prompt medical attention is required if any of these occur.

Mirzaten is contraindicated in patients who have taken monoamine oxidase inhibitors within the past 14 days, those with known hypersensitivity to mirtazapine, and individuals with severe hepatic impairment where dose adjustment is not feasible.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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