Product image of Mirzaten Oro Tab (Mirtazapine) supplied by GNH India

Mirzaten Oro Tab

Active Ingredient:
Mirtazapine
Origin:
EU

Mirzaten Oro Tab (Mirtazapine)

Mirtazapine, the active ingredient in Mirzaten Oro Tab, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as a tablet for oral use. It treats major depressive disorder in adult patients.
GNH India supplies Mirzaten Oro Tab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Mirtazapine is indicated for depressive disorders and related conditions, acting on central neurotransmitter pathways to improve mood.
  • Major depressive disorder: reduces depressive symptoms and improves functional outcomes in adults.
  • Bipolar depressive episodes (adjunct): used as an add‑on therapy to manage depressive phases.
  • Treatment‑resistant depression (adjunct): considered when first‑line agents have not achieved adequate response.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, which enhances serotonergic transmission while reducing serotonergic side‑effects. This combined action elevates mood‑regulating neurotransmitters without directly stimulating serotonin reuptake.

Side Effects

Mirtazapine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Fatigue

Serious or Rare Side Effects

  • Agranulocytosis or severe leukopenia
  • Seizures
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Suicidal ideation or worsening depression
  • Serotonin syndrome when combined with other serotonergic agents
  • Hepatotoxicity (rare)

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety aspects.
  • Assess psychiatric history: monitor for worsening depression or suicidal thoughts.
  • Evaluate hepatic function: dose adjustment may be required in severe impairment.
  • Caution in elderly: increased risk of sedation, falls, and anticholinergic effects.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent withdrawal.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • CNS depressants (e.g., benzodiazepines, alcohol): enhanced sedation and respiratory depression.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): potential serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma concentrations.
  • CYP3A4 inducers (e.g., carbamazepine, phenytoin): may reduce efficacy.
  • Anticholinergic drugs: additive dry‑mouth and constipation effects.

Frequently Asked Questions

Mirzaten Oro Tab contains mirtazapine and is prescribed to treat major depressive disorder in adults. It may also be used as an adjunct in bipolar depressive episodes or in cases of treatment‑resistant depression when other antidepressants have not provided sufficient relief.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and antagonizes 5‑HT2 and 5‑HT3 serotonin receptors. This dual action boosts overall serotonergic and noradrenergic activity, helping to improve mood and alleviate depressive symptoms.

The specific dose is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerability. Typical starting doses are low and may be adjusted gradually, but exact regimens should only be set by a qualified health professional.

Safety data for mirtazapine in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and decisions should be made in consultation with a healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs that primarily inhibit serotonin reuptake. Its receptor profile often results in stronger sedative and appetite‑stimulating effects, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those concerned about these side effects.

Store tablets at ambient temperature, preferably below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Mirzaten Oro Tab is taken orally, usually once daily in the evening. Swallow the tablet whole with a glass of water; it may be taken with or without food, but consistent timing helps maintain stable blood levels.

Serious risks include agranulocytosis or severe leukopenia, seizures, hypersensitivity reactions such as Stevens‑Johnson syndrome, worsening depression or suicidal thoughts, and serotonin syndrome when combined with other serotonergic drugs. Immediate medical attention is required if any of these occur.

Mirtazapine is contraindicated in patients with known hypersensitivity to the drug, those currently taking monoamine oxidase inhibitors, or individuals with severe hepatic impairment where dose adjustment is not feasible. Caution is also advised for patients with a history of bipolar disorder who may switch to mania without proper monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.