Product image of Mirzaten Q-Tab (Mirtazapine) supplied by GNH India

Mirzaten Q-Tab

Active Ingredient:
Mirtazapine
Origin:
EU

Mirzaten Q-Tab (Mirtazapine)

Mirtazapine, the active ingredient in Mirzaten Q-Tab, is a tetracyclic antidepressant presented as a tablet for oral use. It is prescribed for the treatment of major depressive disorder in adult patients, helping to alleviate depressive symptoms by modulating neurotransmitter activity and is classified under ATC code N06AX11.

GNH India supplies Mirzaten Q-Tab as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Mirtazapine is indicated for depressive disorders and works within the serotonergic and noradrenergic pathways to improve mood.

  • Major depressive disorder: reduction of depressive symptoms in adult patients.
  • Depressive episodes: improvement of mood and functional status during acute episodes.
  • Treatment‑resistant depression: option when other antidepressants have not provided adequate response.

How It Works

  • Mirtazapine antagonizes central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and blocks 5‑HT2 and 5‑HT3 receptors, which enhances serotonergic neurotransmission while reducing associated side effects. This combined action raises overall levels of norepinephrine and serotonin in the CNS, contributing to its antidepressant effect.

Side Effects

Common Side Effects

  • Sedation or drowsiness.
  • Increased appetite and weight gain.
  • Dry mouth.
  • Constipation.
  • Dizziness.
  • Enhanced cholesterol levels.

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe hypersensitivity reactions.
  • Suicidal thoughts or behavior, especially early in therapy.
  • Serotonin syndrome when combined with other serotonergic agents.
  • Hepatotoxicity or liver enzyme elevation.

Precautions & Warnings

Before initiating therapy, consider the following precautions:

  • Assess hepatic function: adjust use in severe liver impairment.
  • Monitor for worsening depression or emergence of suicidal ideation.
  • Use caution in patients with a history of bipolar disorder or mania.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce withdrawal risk.
  • Evaluate risk versus benefit in pregnancy and lactation, as safety data are limited.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Mirtazapine may interact with several drug classes; monitoring is essential.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis and serotonin syndrome.
  • Linezolid or other reversible MAO inhibitors.
  • Other serotonergic agents (e.g., SSRIs, SNRIs) when combined may precipitate serotonin syndrome.
  • Central nervous system depressants (e.g., benzodiazepines, alcohol) can intensify sedation.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma levels.
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise exposure.
  • Alcohol: can enhance sedative effects.
  • Antihistamines: additive drowsiness.
  • Other antidepressants: may require dose adjustment and close observation.

Frequently Asked Questions

Mirzaten Q-Tab contains mirtazapine, which is prescribed primarily for major depressive disorder in adult patients. It helps relieve depressive symptoms by enhancing norepinephrine and serotonin activity in the brain, thereby improving mood, sleep, and appetite.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, leading to increased release of norepinephrine. It also antagonizes 5‑HT2 and 5‑HT3 receptors, which boosts overall serotonin transmission while reducing certain serotonin‑related side effects. This dual action contributes to its antidepressant effect.

The appropriate dose of Mirzaten Q-Tab is determined by the prescribing healthcare professional based on the individual’s clinical condition, response to therapy, and tolerability. Dosage may be adjusted over time, and patients should follow the prescriber’s instructions precisely.

The safety of mirtazapine in pregnancy and lactation has not been definitively established, and the product carries an unknown pregnancy category. Clinicians must weigh potential benefits against possible risks and discuss these considerations with the patient before use.

To place an order, submit an enquiry on the Mirzaten Q-Tab product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine often causes more sedation and weight gain but may be beneficial for patients with insomnia or poor appetite. Its distinct receptor profile can be advantageous when SSRIs are ineffective or poorly tolerated.

Store Mirzaten Q-Tab at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct light to maintain potency throughout the shelf life.

Mirzaten Q-Tab is taken orally, usually once daily in the evening with or without food, as directed by the prescriber. Swallow the tablet whole; do not crush, split, or chew unless specifically instructed.

Serious risks include the potential for agranulocytosis, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, suicidal thoughts especially early in treatment, and serotonin syndrome when combined with other serotonergic drugs. Prompt medical attention is required if any of these occur.

Patients with known hypersensitivity to mirtazapine or any tablet excipients should avoid it. It is also contraindicated in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those who have experienced severe reactions to similar antidepressants. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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