Product image of Mirzaten Q-Tab (Mirtazapine) supplied by GNH India

Mirzaten Q-Tab

Active Ingredient:
Mirtazapine
Origin:
EU

Mirzaten Q-Tab (Mirtazapine)

Mirtazapine, the active ingredient in Mirzaten Q-Tab, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as a tablet for oral use. It treats major depressive disorder in adults.
GNH India supplies Mirzaten Q-Tab as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Mirtazapine is indicated for depressive disorders and related conditions.

  • Major depressive disorder: alleviates depressive symptoms and improves mood.
  • Depressive episodes with prominent insomnia: helps restore sleep while treating depression.
  • Depression with significant anxiety: reduces anxiety symptoms alongside antidepressant effect.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and antagonizes postsynaptic 5‑HT2, 5‑HT3 and histamine H1 receptors. This combined action enhances serotonergic and noradrenergic neurotransmission while producing sedative effects, contributing to its antidepressant efficacy.

Side Effects

Mirtazapine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Peripheral edema

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Suicidal thoughts or behavior, especially early in treatment
  • Severe hypotension or syncope
  • Hepatic dysfunction or hepatitis
  • Seizures

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Hepatic function: assess liver enzymes in patients with liver disease.
  • Suicidal risk: monitor for emergent suicidal thoughts, particularly in the first weeks.
  • Elderly patients: use caution due to increased sedation and fall risk.
  • Discontinuation: avoid abrupt cessation to reduce withdrawal symptoms.
  • Concomitant CNS depressants: evaluate additive sedative effects.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mirtazapine can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis and serotonin syndrome.
  • Other serotonergic agents (e.g., SSRIs, SNRIs, tramadol): heightened serotonin syndrome potential.
  • Potent CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): may increase mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors or inducers (e.g., ketoconazole, rifampin): may alter drug exposure.
  • CNS depressants (e.g., benzodiazepines, alcohol): additive sedation.
  • Antihistamines: increased drowsiness.
  • Warfarin: monitor INR for possible anticoagulant effect changes.
  • Lithium: watch for enhanced neurotoxic signs.

Frequently Asked Questions

Mirzaten Q-Tab contains mirtazapine, an antidepressant indicated primarily for the treatment of major depressive disorder in adult patients. It helps relieve depressive symptoms such as low mood, loss of interest, and impaired concentration.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonizing postsynaptic 5‑HT2, 5‑HT3 and histamine H1 receptors. This dual action enhances serotonergic and noradrenergic neurotransmission while providing a sedative effect that can improve sleep.

The appropriate dose of Mirzaten Q-Tab is determined by the prescribing clinician based on the individual’s clinical condition, response to therapy, and tolerability. Dosage adjustments are made according to professional guidelines and patient needs.

The safety of mirtazapine in pregnancy and lactation has not been definitively established. Healthcare providers should weigh potential benefits against possible risks and consider alternative treatments when treating pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct receptor profile that often results in greater sedation and appetite stimulation. It may be preferred when insomnia or weight loss are concerns, but individual response and side‑effect tolerance guide the choice of therapy.

Mirzaten Q-Tab should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and store them out of reach of children.

Mirzaten Q-Tab is taken orally, usually once daily in the evening with or without food, as directed by the prescribing clinician. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include the potential for agranulocytosis, severe hepatic injury, and the emergence of suicidal thoughts or behaviors, especially during the initial treatment period. Patients should be monitored closely for any signs of infection, liver dysfunction, or worsening mood.

Mirtazapine is contraindicated in patients who are currently taking monoamine oxidase inhibitors (MAOIs) or have a known hypersensitivity to the drug. Caution is also advised for individuals with severe hepatic impairment, uncontrolled hypertension, or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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