Product image of Misar Sr (Alprazolam) supplied by GNH India

Misar Sr

Active Ingredient:
Alprazolam
Origin:
EU

Misar Sr (Alprazolam)

Alprazolam, the active ingredient in Misar Sr, is a benzodiazepine presented as a tablet for oral use. It is prescribed to manage anxiety disorders, including generalized anxiety disorder and panic disorder, in adult patients, and works by enhancing the inhibitory action of GABA in the central nervous system to provide rapid relief of anxiety symptoms.

GNH India supplies Misar Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

Alprazolam is a benzodiazepine that acts on the central nervous system to alleviate anxiety‑related conditions.

  • Generalized anxiety disorder: reduces excessive worry and tension in adult patients.
  • Panic disorder: diminishes the frequency and severity of panic attacks.

How It Works

  • Alprazolam binds to a specific site on the GABA_A receptor complex, acting as a positive allosteric modulator. This increases the frequency of chloride channel opening events when GABA binds, enhancing neuronal inhibition and producing a calming effect throughout the central nervous system.

Side Effects

Common side effects are generally mild and transient, while serious or rare reactions require immediate medical attention.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Impaired coordination: reduced motor control and balance.
  • Memory impairment: difficulty recalling recent events.
  • Blurred vision: temporary visual disturbances.
  • Fatigue: persistent lack of energy.

Serious or Rare Side Effects

  • Respiratory depression: slowed or shallow breathing.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Depression or suicidal thoughts: mood changes requiring urgent care.
  • Dependence or withdrawal syndrome: physical reliance after prolonged use.
  • Seizures: rare occurrence during abrupt discontinuation.
  • Hepatic dysfunction: abnormal liver enzyme elevations.

Precautions & Warnings

Before prescribing Misar Sr, clinicians should evaluate patient history and monitor for specific safety concerns.

  • Substance abuse assessment: screen for prior benzodiazepine or opioid misuse.
  • Discontinuation plan: avoid abrupt cessation to prevent withdrawal.
  • Hepatic impairment: adjust use in patients with liver disease.
  • Respiratory monitoring: watch for depression when combined with other CNS depressants.
  • Concomitant CNS depressants: use caution with alcohol, antihistamines, or sleep aids.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Alprazolam may interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • Other benzodiazepines: additive sedative effects.
  • Opioids: heightened risk of respiratory depression.
  • Alcohol: synergistic CNS depression.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase alprazolam levels.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may reduce therapeutic effect.
  • Selective serotonin reuptake inhibitors (SSRIs): monitor for enhanced sedation.

Frequently Asked Questions

Misar Sr contains alprazolam, a benzodiazepine prescribed to treat anxiety‑related conditions such as generalized anxiety disorder and panic disorder in adult patients. It helps reduce excessive worry, tension, and the frequency of panic attacks by enhancing the calming effects of the neurotransmitter GABA in the brain.

Alprazolam binds to a specific site on the GABA_A receptor complex, acting as a positive allosteric modulator. This increases the opening of chloride channels when GABA binds, leading to greater neuronal inhibition and a calming effect throughout the central nervous system, which alleviates anxiety symptoms.

The appropriate dose of Misar Sr is determined by the prescribing clinician based on the individual’s medical condition, age, response to therapy, and other factors. Patients should follow the prescriber’s instructions and never adjust the dose without medical guidance.

Safety data for alprazolam in pregnancy and lactation are limited. It is generally advised to avoid use during pregnancy unless the potential benefit justifies the risk, and breastfeeding mothers should discuss alternatives with their healthcare provider, as the drug can be excreted in breast milk.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Misar Sr (alprazolam) is a short‑acting benzodiazepine, offering rapid onset of anxiety relief compared with longer‑acting agents such as diazepam. While effective for acute anxiety and panic attacks, its shorter half‑life may require careful dosing to avoid rebound symptoms, and it carries a higher potential for dependence than some non‑benzodiazepine alternatives.

Misar Sr should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged or the tablets appear discolored.

Misar Sr is taken orally, usually with or without food, as directed by a healthcare professional. The tablets should be swallowed whole with a glass of water and not chewed, crushed, or broken unless specifically instructed by the prescriber.

Serious risks include respiratory depression, especially when combined with other central nervous system depressants, severe allergic reactions, dependence and withdrawal syndrome, and rare occurrences of seizures or severe mood changes such as depression or suicidal thoughts. Patients should seek immediate medical attention if any of these symptoms arise.

Misar Sr is contraindicated in individuals with known hypersensitivity to alprazolam or other benzodiazepines, those with acute narrow‑angle glaucoma, and patients who are currently dependent on alcohol or other central nervous system depressants. Caution is also advised for patients with severe respiratory insufficiency, severe hepatic impairment, or a history of substance abuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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