Misofenac (Diclofenac Sodium, Misoprostol)

Diclofenac sodium blocks cyclo‑oxygenase‑1 and cyclo‑oxygenase‑2, lowering prostaglandin production and thus reducing pain and inflammation. Misoprostol mimics prostaglandin E1, stimulating gastric mucus and bicarbonate secretion and improving mucosal blood flow, which together safeguard the stomach from NSAID‑related damage.

The appropriate dose of Misofenac is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other relevant factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Misofenac is classified as pregnancy category X, meaning it is contraindicated during pregnancy because of potential fetal harm, including premature closure of the ductus arteriosus. Use while breastfeeding is not recommended unless the benefits outweigh the risks, and a healthcare provider should be consulted.

To order Misofenac, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then replies with pricing, availability, shipping details and any required import documentation.

Misofenac uniquely combines diclofenac, a potent NSAID, with misoprostol, a prostaglandin E1 analogue that directly protects the gastric lining. Compared with NSAID‑only products, it offers comparable analgesic efficacy while providing built‑in ulcer prophylaxis, potentially reducing the need for separate proton‑pump inhibitors or H2 blockers.

Misofenac should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date indicated on the label.

Misofenac is taken orally, usually with a full glass of water. It may be taken with or without food, but patients who experience stomach upset are advised to take it with meals to lessen gastrointestinal discomfort.

Serious risks include gastrointestinal bleeding or ulceration, severe liver injury, acute kidney impairment, hypersensitivity reactions such as Stevens‑Johnson syndrome, and cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they notice signs such as black stools, jaundice, sudden swelling, or severe skin rash.

Misofenac should be avoided in individuals with known hypersensitivity to diclofenac, misoprostol, or any component of the formulation. It is also contraindicated in pregnant women, patients with active peptic ulcer disease, severe heart failure, uncontrolled hypertension, and those taking certain interacting medications without close medical supervision.