Product image of Misoone (Misoprostol) supplied by GNH India

Misoone

Active Ingredient:
Misoprostol
Origin:
EU

Misoone (Misoprostol)

Misoprostol, the active ingredient in Misoone, is a prostaglandin analog presented as a tablet for oral use. It is used to protect the gastric lining in patients taking NSAIDs and to induce uterine contractions for obstetric purposes.
GNH India supplies Misoone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Exelgyn Sa

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Indications & Clinical Uses

Misoprostol, a prostaglandin analog, is employed in several therapeutic areas related to gastric protection and obstetric management.

  • Prevention of NSAID‑induced gastric ulcers: reduces ulcer formation in patients receiving non‑steroidal anti‑inflammatory drugs.
  • Medical termination of pregnancy: induces uterine contraction to terminate early pregnancy.
  • Induction of labor: promotes cervical ripening and uterine activity to initiate labor.

How It Works

  • Misoprostol is a synthetic prostaglandin E1 (PGE1) analog that binds to prostaglandin EP receptors. In the gastrointestinal tract it stimulates mucus and bicarbonate secretion while inhibiting gastric acid production, enhancing mucosal protection. In the uterus it activates EP receptors on smooth muscle, increasing intracellular calcium and causing coordinated uterine contractions.

Side Effects

Misoprostol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort.
  • Nausea: feeling of sickness.
  • Headache: mild to moderate pain.
  • Fever: low‑grade temperature elevation.
  • Vaginal bleeding: spotting or bleeding.

Serious or Rare Side Effects

  • Severe uterine hyperstimulation: excessive contractions that may compromise fetal oxygenation.
  • Gastrointestinal ulcer perforation: rare but serious breach of the stomach wall.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Cardiovascular events: rare cases of myocardial infarction.
  • Severe dehydration: from persistent vomiting or diarrhea.

Precautions & Warnings

Before prescribing Misoprostol, clinicians should consider several safety aspects.

  • Contraindication in known hypersensitivity: discontinue if allergic reaction occurs.
  • Caution in cardiovascular disease: monitor for chest pain or ischemic symptoms.
  • Avoid in active peptic ulcer disease: may exacerbate ulceration.
  • Use with caution during pregnancy: only indicated for specific obstetric indications under medical supervision.
  • Monitor renal or hepatic impairment: adjust therapy as clinically indicated.
  • Store at ambient temperature: keep below 25°C, retain in original packaging, protect from moisture and light.

Avoid Interactions

Misoprostol can interact with other medicines, affecting efficacy or safety.

Major Interactions (Avoid)

  • NSAIDs: may reduce gastroprotective effect, increasing ulcer risk.
  • Antacids containing aluminum or magnesium: can decrease absorption of Misoprostol.

Moderate Interactions (Monitor Closely)

  • Anticoagulants (e.g., warfarin): potential for increased bleeding risk.
  • Oxytocin: additive uterine contractile effect may cause hyperstimulation.
  • Rifampin: may lower plasma levels of Misoprostol, reducing effectiveness.

Frequently Asked Questions

Misoone contains misoprostol, which is used to prevent gastric ulcers in patients taking NSAIDs, to medically terminate early pregnancy, and to induce labor by promoting uterine contractions and cervical ripening.

Misoprostol mimics prostaglandin E1, binding to EP receptors. In the stomach it increases mucus and bicarbonate while lowering acid secretion, and in the uterus it raises intracellular calcium, causing smooth‑muscle contraction.

The specific dose of Misoone is determined by the prescribing clinician based on the indication, patient characteristics, and local guidelines. Dosage regimens are not standardized in public information.

Misoprostol is contraindicated in pregnancy except when used for medically indicated termination or labor induction under professional supervision. Safety during breastfeeding has not been established, so use is generally avoided.

To order Misoone, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Misoone (misoprostol) is a synthetic PGE1 analog, whereas other agents like dinoprostone are PGE2 analogs. Misoprostol is more stable at room temperature and is commonly used for ulcer prophylaxis and obstetric indications, while PGE2 agents are often preferred for cervical ripening due to different receptor affinities.

Misoone should be stored at ambient temperature, below 25 °C, in its original packaging. Keep it away from moisture, direct sunlight, and excessive heat to maintain potency.

Misoone is administered orally as a tablet. The exact administration schedule, such as timing relative to meals or other medications, is determined by the prescribing healthcare professional.

Serious risks include severe uterine hyperstimulation, which can compromise fetal oxygenation, gastrointestinal ulcer perforation, and rare allergic reactions such as anaphylaxis. Patients should be monitored closely for these events.

Misoone should not be used by individuals with known hypersensitivity to misoprostol or other prostaglandin analogs, patients with active peptic ulcer disease, and those for whom uterine contraction is contraindicated unless specifically indicated under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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