Product image of Misoone (Misoprostol) supplied by GNH India

Misoone

Active Ingredient:
Misoprostol
Origin:
EU

Misoone (Misoprostol)

Misoprostol, the active ingredient in Misoone, is a prostaglandin analog presented as an oral dosage form for oral use. It is used to prevent NSAID‑induced gastric ulcers and to induce uterine contractions for medical termination of pregnancy and labor induction.

GNH India supplies Misoone as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Exelgyn Sa

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Indications & Clinical Uses

Misoprostol belongs to the prostaglandin analog class and is employed in gastrointestinal protection and obstetric procedures.

  • Prevention of NSAID‑induced gastric ulcers: reduces ulcer risk by enhancing gastric mucus and lowering acid secretion.
  • Medical termination of pregnancy: induces uterine contractions to facilitate expulsion of gestational tissue.
  • Induction of labor: promotes cervical ripening and uterine activity to assist vaginal delivery.

How It Works

  • Misoprostol is a synthetic prostaglandin E1 (PGE1) analog that binds to EP receptors on gastric mucosal cells, stimulating mucus and bicarbonate secretion while inhibiting gastric acid production. In the uterus, it activates EP3 receptors on smooth‑muscle cells, leading to increased intracellular calcium and coordinated uterine contractions.

Side Effects

Misoprostol may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Diarrhea: frequent loose stools.
  • Abdominal pain: cramping or discomfort in the stomach area.
  • Nausea: feeling of unease and urge to vomit.
  • Vomiting: expulsion of stomach contents.
  • Fever: mild elevation of body temperature.
  • Chills: sensation of cold with shivering.

Serious or Rare Side Effects

  • Uterine rupture: tearing of the uterine wall, a medical emergency.
  • Severe hemorrhage: excessive bleeding that may require transfusion.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Hypotension: marked drop in blood pressure leading to dizziness or fainting.

Precautions & Warnings

Before prescribing Misoprostol, clinicians should consider several safety measures.

  • Assess renal function: avoid use in patients with severe renal impairment.
  • Active peptic ulcer disease: contraindicated in patients with existing ulceration.
  • Cardiovascular disease: use with caution due to potential hemodynamic effects.
  • Hypersensitivity: do not administer to individuals with known prostaglandin allergy.
  • Pregnancy: consult obstetric specialist; drug can cause uterine contractions.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Misoprostol can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • NSAIDs: concurrent use may diminish gastroprotective benefit.
  • Oxytocin: additive uterine stimulation can increase risk of hyperstimulation.
  • Anticoagulants: may heighten bleeding risk.

Moderate Interactions (Monitor Closely)

  • Antacids: can affect absorption and reduce efficacy.
  • Antihypertensives: may cause additive hypotensive effects.

Frequently Asked Questions

Misoone contains misoprostol, which is used to prevent gastric ulcers caused by non‑steroidal anti‑inflammatory drugs, to medically terminate early pregnancies, and to induce labor by promoting uterine contractions and cervical ripening.

Misoprostol is a synthetic prostaglandin E1 analog that binds to EP receptors in the stomach and uterus. In the stomach it increases mucus and bicarbonate secretion while reducing acid output; in the uterus it raises intracellular calcium, causing smooth‑muscle contraction.

The dosage of Misoone is determined by the prescribing clinician based on the specific indication, patient characteristics, and local treatment guidelines. Patients should follow the exact regimen provided by their healthcare professional.

Misoprostol can induce uterine contractions and is therefore contraindicated for use in pregnancy unless specifically indicated for termination or labor induction under medical supervision. Safety during breastfeeding has not been established, and a healthcare provider should be consulted.

To order Misoone, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Misoone (misoprostol) is a prostaglandin E1 analog, whereas other agents such as dinoprostone are prostaglandin E2 analogs. Misoprostol is more stable at room temperature and can be administered orally, while some alternatives require vaginal or injectable routes and may have different side‑effect profiles.

Misoone should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct light to maintain its stability and potency.

Misoone is supplied as an oral formulation. It is taken by mouth with water, following the dosing schedule prescribed by the healthcare professional. The exact timing and frequency depend on the therapeutic indication.

Serious risks include uterine rupture, severe hemorrhage, allergic reactions such as anaphylaxis, and significant hypotension. Patients should be monitored closely for these events, especially when used for obstetric purposes.

Misoone should not be used by individuals with known hypersensitivity to misoprostol or other prostaglandins, patients with active peptic ulcer disease, severe renal impairment, or those for whom uterine contraction is contraindicated unless specifically indicated under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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