Product image of Misoprostol Exelgyn (Misoprostol) supplied by GNH India

Misoprostol Exelgyn

Active Ingredient:
Misoprostol
Origin:
EU

Misoprostol Exelgyn (Misoprostol)

Misoprostol, the active ingredient in Misoprostol Exelgyn, is a prostaglandin E1 analog presented as an oral formulation for oral use. It is employed to protect the gastric mucosa in patients taking NSAIDs and to induce uterine contractility for obstetric indications, addressing both gastrointestinal and reproductive health needs.

GNH India supplies Misoprostol Exelgyn as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Exelgyn Sa

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Indications & Clinical Uses

Misoprostol acts on prostaglandin pathways to provide gastroprotective and obstetric effects.

  • Prevention of NSAID‑induced gastric ulcers: reduces ulcer risk by enhancing mucus production and decreasing gastric acid secretion.
  • Medical termination of pregnancy: induces uterine contractions and cervical softening to facilitate expulsion of pregnancy tissue.
  • Induction of labor: promotes cervical ripening and uterine activity to initiate childbirth.
  • Management of postpartum hemorrhage: stimulates uterine contraction to control bleeding after delivery.

How It Works

  • Misoprostol is a synthetic analogue of prostaglandin E1 that binds to EP receptors on gastric mucosal cells and uterine smooth muscle. In the stomach, receptor activation increases mucus and bicarbonate secretion while inhibiting acid production. In the uterus, it triggers calcium‑mediated contraction and cervical remodeling, facilitating labor or abortion.

Side Effects

Misoprostol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Vomiting
  • Fever
  • Chills

Serious or Rare Side Effects

  • Uterine rupture
  • Severe postpartum hemorrhage
  • Anaphylactic reaction
  • Cardiovascular collapse
  • Severe abdominal pain with peritonitis

Precautions & Warnings

When prescribing Misoprostol, clinicians should observe several safety measures.

  • Assess ulcer risk: evaluate patient history of NSAID use and gastrointestinal disease.
  • Evaluate pregnancy status: confirm gestational age before obstetric use.
  • Review concomitant NSAID therapy: avoid high‑dose NSAIDs that may counteract protection.
  • Monitor uterine activity: observe for hyperstimulation during labor induction.
  • Adjust for organ impairment: consider dose modification in severe renal or hepatic dysfunction.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Misoprostol can interact with other medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Concurrent use with other uterotonic agents (e.g., oxytocin, carboprost) may cause excessive uterine contraction.
  • Combination with anticoagulants (e.g., warfarin, heparin) can increase the risk of severe bleeding.
  • Co‑administration with high‑dose NSAIDs may diminish gastric protective effect.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium may reduce oral absorption of misoprostol.
  • Rifampin and other enzyme inducers can lower plasma concentrations, reducing effectiveness.
  • Corticosteroids may enhance gastrointestinal side effects when used together.

Frequently Asked Questions

Misoprostol Exelgyn is used to prevent gastric ulcers in patients receiving NSAIDs, to medically terminate early pregnancies, to induce labor by promoting cervical ripening and uterine contractions, and to manage postpartum hemorrhage by stimulating uterine tone.

Misoprostol mimics prostaglandin E1 and binds to EP receptors on gastric and uterine tissues. In the stomach, this binding increases protective mucus and bicarbonate while reducing acid secretion. In the uterus, it raises intracellular calcium, leading to smooth‑muscle contraction and cervical softening.

The dose of Misoprostol Exelgyn is determined by the prescribing healthcare professional based on the specific indication, patient weight, gestational age (for obstetric use), and any concomitant medications. Only a qualified prescriber should set the regimen.

Misoprostol is contraindicated in pregnancy except when used intentionally for termination or labor induction under medical supervision. Its safety during breastfeeding has not been established, so clinicians should weigh potential risks and benefits before prescribing.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Misoprostol is a prostaglandin analogue that can be administered orally, offering convenience compared with injectable agents like oxytocin. It has a well‑characterised safety profile but may cause more gastrointestinal side effects. Choice of agent depends on clinical setting, route preference and patient-specific factors.

Misoprostol Exelgyn should be stored at temperatures below 25 °C, in its original packaging, protected from moisture, heat and direct light. Maintaining these conditions helps preserve potency and stability throughout its shelf life.

The product is supplied for oral administration. It is taken with water, usually on an empty stomach for gastric‑ulcer prevention, or as directed by a clinician for obstetric indications. Exact timing and dosing schedule are determined by the prescriber.

Serious risks include uterine rupture, severe postpartum hemorrhage, anaphylactic reactions, cardiovascular collapse, and severe abdominal pain indicating possible perforation. Patients should be monitored closely for these events, especially when used for labor induction or abortion.

Misoprostol Exelgyn is contraindicated in patients with known hypersensitivity to misoprostol or other prostaglandins, in women with a viable intrauterine pregnancy when not intended for termination, and in individuals with severe cardiac, hepatic or renal disease where uterine hyperstimulation could be hazardous.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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