Product image of Mispregnol (Misoprostol) supplied by GNH India

Mispregnol

Active Ingredient:
Misoprostol
Origin:
EU

Mispregnol (Misoprostol)

Misoprostol, the active ingredient in Mispregnol, is a prostaglandin analog presented as an oral tablet for oral use. It is employed to prevent NSAID‑induced gastric ulcers and to manage obstetric conditions such as medical abortion, induction of labor, and postpartum hemorrhage.

GNH India supplies Mispregnol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The product complies with EU quality standards and is distributed to health‑care providers across multiple regions. Its manufacturing follows Good Manufacturing Practice (GMP) and each batch undergoes rigorous testing for purity and potency.

Manufacturer / TM Owner

Exelgyn Sa

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Indications & Clinical Uses

Misoprostol acts on prostaglandin pathways to provide gastroprotective and uterotonic effects.

  • NSAID‑induced gastric ulcer prevention: reduces gastric acid secretion and enhances mucosal protection, lowering ulcer incidence.
  • Medical abortion: induces uterine contractions and cervical softening to terminate early pregnancy.
  • Induction of labor: promotes cervical ripening and stimulates uterine activity to facilitate delivery.
  • Management of postpartum hemorrhage: contracts uterine muscle to reduce bleeding after childbirth.

How It Works

  • Misoprostol is a synthetic analogue of prostaglandin E1 that binds to EP receptors on gastric mucosa and uterine smooth muscle. In the stomach it inhibits proton pump activity, stimulates mucus and bicarbonate secretion, and enhances mucosal blood flow, thereby protecting against acid injury. In the uterus it activates EP2 and EP3 receptors, increasing intracellular calcium and promoting coordinated uterine contractions, thereby facilitating effective labor.

Side Effects

Misoprostol may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Abdominal pain: cramping or discomfort in the stomach area.
  • Diarrhea: loose, watery stools.
  • Nausea: feeling of sickness or urge to vomit.

Serious or Rare Side Effects

  • Uterine hyperstimulation: excessively strong or frequent contractions.
  • Anaphylaxis: life‑threatening allergic reaction with rash, swelling, and breathing difficulty.
  • Severe postpartum hemorrhage: uncontrolled bleeding despite treatment.

Precautions & Warnings

When using Misoprostol, several precautions should be observed to minimize risks.

  • Assess renal function: dose adjustment may be needed in impaired kidneys.
  • Evaluate NSAID use: concurrent NSAIDs can diminish gastroprotective benefit.
  • Monitor uterine activity: careful observation required in pregnant patients to avoid excessive contractions.
  • Avoid in known hypersensitivity: discontinue if allergic reactions occur.
  • Use caution with cardiovascular disease: prostaglandin effects may affect blood pressure.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Misoprostol interacts with several medicines; awareness of these interactions helps ensure safe therapy.

Major Interactions (Avoid)

  • Concomitant uterotonic agents: may cause excessive uterine contraction.
  • High‑dose NSAIDs: can reduce Misoprostol’s gastroprotective efficacy.
  • Anticoagulants: increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may enhance hypotensive effect.
  • Corticosteroids: combined use may increase gastrointestinal irritation.
  • Macrolide antibiotics: may alter Misoprostol metabolism.

Frequently Asked Questions

Mispregnol contains misoprostol, which is used to prevent gastric ulcers caused by non‑steroidal anti‑inflammatory drugs (NSAIDs) and to manage obstetric conditions such as medical abortion, induction of labor, and control of postpartum hemorrhage.

Misoprostol is a synthetic prostaglandin E1 analogue. It binds to EP receptors in the stomach to inhibit acid secretion and increase mucus and bicarbonate production, while in the uterus it activates receptors that raise intracellular calcium, producing coordinated uterine contractions.

The dose of Mispregnol is determined by the prescribing clinician based on the specific indication, patient characteristics, and clinical guidelines. No standard dosing regimen is provided here; the prescriber will set the appropriate amount.

Misoprostol’s pregnancy category is listed as unknown, and it can induce uterine contractions. It should be used with caution and only when clearly indicated. Breastfeeding safety has not been established, so risk‑benefit assessment by a healthcare professional is essential.

To order Mispregnol, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Unlike proton‑pump inhibitors, misoprostol works by mimicking prostaglandin activity to increase mucosal defenses while also reducing acid output. It offers the added benefit of uterotonic activity, making it useful for obstetric indications, but it may have a higher incidence of gastrointestinal side effects compared with some alternatives.

Mispregnol should be stored at room temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and avoid storing in humid environments such as bathrooms.

Mispregnol is administered orally as a tablet. The exact route (with or without food) and timing depend on the indication and the prescribing clinician’s instructions.

Serious risks include uterine hyperstimulation, severe postpartum hemorrhage, and rare allergic reactions such as anaphylaxis. Patients should be monitored for signs of excessive uterine activity, uncontrolled bleeding, or any sudden allergic symptoms.

Mispregnol should be avoided in individuals with known hypersensitivity to misoprostol or other prostaglandin analogues, in patients with severe cardiovascular disease where prostaglandin effects may be harmful, and in situations where uterine contractions are contraindicated unless specifically indicated by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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