Mistick Antistaminico (Promethazine Hydrochloride)

Promethazine blocks histamine H1 receptors on peripheral tissues, preventing histamine from causing vasodilation, increased permeability, and nerve activation that lead to itching and swelling. Its additional anticholinergic and anti‑serotonergic actions contribute to its antipruritic and mild sedative properties when absorbed systemically.

The appropriate amount of Mistick Antistaminico is determined by the prescribing healthcare professional based on the severity of the skin condition, patient age, and other clinical factors. Patients should follow the prescriber’s instructions and not exceed the recommended application frequency.

Safety data for topical promethazine during pregnancy and lactation are limited. The prescriber should weigh potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Compared with newer, second‑generation antihistamines, promethazine has a broader pharmacologic profile, including anticholinergic and sedative effects, which can be advantageous for severe itching but may cause more drowsiness. It is often chosen for topical use when rapid antipruritic action is needed, whereas non‑sedating agents are preferred for systemic therapy.

Store the product at ambient temperature, preferably below 25 °C, in its original packaging. Protect it from moisture, direct sunlight, and extreme temperatures. Keep the container tightly closed when not in use and out of reach of children.

Mistick Antistaminico is applied topically to the affected skin area. Clean and gently dry the skin before applying a thin layer of the product, usually once or twice daily as directed by the prescriber. Avoid contact with eyes, mucous membranes, and broken skin.

Serious risks include severe allergic reactions such as angio‑edema or anaphylaxis, rare but life‑threatening skin conditions like Stevens‑Johnson syndrome, and systemic effects such as significant sedation, cardiac arrhythmias (QT prolongation), and anticholinergic toxicity. Immediate medical attention is required if any of these occur.

Individuals with known hypersensitivity to promethazine, other phenothiazines, or any component of the formulation should avoid use. It is also contraindicated in patients taking monoamine oxidase inhibitors within the past 14 days, those with significant cardiac conduction disorders, and patients for whom sedation could be hazardous, such as those operating machinery.