Misyo (Methadone Hydrochloride)

Methadone hydrochloride acts as a full agonist at the μ‑opioid receptor, blocking pain signals in the central nervous system, while also antagonizing NMDA receptors and inhibiting serotonin and norepinephrine reuptake, which together aid in withdrawal suppression and sustained analgesia.

The appropriate dose of Misyo is individualized by the prescribing clinician based on the patient’s opioid tolerance, clinical condition, response to therapy, and any relevant comorbidities; no standard dosing regimen is provided here.

Safety data for methadone hydrochloride in pregnancy and lactation are limited; clinicians should weigh potential benefits against risks and consider alternative therapies, following local regulatory guidance and obstetric recommendations.

To request Misyo, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with buprenorphine, another opioid used for dependence, methadone provides full μ‑receptor activation and a longer half‑life, allowing once‑daily dosing but carries a higher risk of respiratory depression; choice depends on patient‑specific factors and treatment goals.

Misyo should be stored at ambient temperature, below 25 °C, in its original packaging to protect from moisture and light. Keep the product out of reach of children and avoid exposure to extreme temperatures.

Misyo is taken orally, usually with a glass of water. It may be administered with or without food, but consistent intake with respect to meals helps maintain stable plasma concentrations.

The most critical risks include respiratory depression, especially in opioid‑naïve patients, QT interval prolongation that can lead to arrhythmias, and rare severe allergic reactions such as anaphylaxis; immediate medical attention is required if these occur.

Misyo is contraindicated in patients with known hypersensitivity to methadone, those currently experiencing acute intoxication with alcohol or other central nervous system depressants, and individuals with severe uncontrolled cardiac arrhythmias or significant respiratory compromise.