Product image of Mitabor Disper (Mirtazapine) supplied by GNH India

Mitabor Disper

Active Ingredient:
Mirtazapine
Origin:
EU

Mitabor Disper (Mirtazapine)

Mirtazapine, the active ingredient in Mitabor Disper, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It treats major depressive disorder in adults. GNH India supplies Mitabor Disper as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Mirtazapine acts on central neurotransmitter pathways to alleviate depressive conditions.

  • Major depressive disorder: reduces depressive symptoms and improves mood in adult patients.
  • Depression with insomnia: helps restore sleep quality while treating depressive mood.
  • Depression with anxiety features: may lessen anxiety symptoms alongside mood improvement.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and selectively antagonizes 5‑HT2 and 5‑HT3 receptors while strongly inhibiting H1 histamine receptors. This combined action enhances noradrenergic and serotonergic neurotransmission, contributing to its antidepressant effect.

Side Effects

Mirtazapine may cause a range of adverse reactions.

Common Side Effects

  • Sedation or drowsiness
  • Increased appetite and weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Orthostatic hypotension

Serious or Rare Side Effects

  • Agranulocytosis or severe neutropenia
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Seizures
  • Suicidal thoughts or behavior, especially early in treatment
  • Hepatic dysfunction or jaundice
  • Unexplained fever or rash

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Assess hepatic function: adjust use in severe liver impairment.
  • Monitor weight: significant weight gain may occur.
  • Evaluate for suicidal ideation: especially during the first weeks of treatment.
  • Use caution in patients with cardiovascular disease: may cause orthostatic hypotension.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Mirtazapine can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Strong CYP1A2 inhibitors (e.g., fluvoxamine): may raise mirtazapine plasma levels.
  • Central nervous system depressants (alcohol, benzodiazepines): enhanced sedation.

Moderate Interactions (Monitor Closely)

  • CYP2D6 substrates (e.g., codeine): altered metabolism may occur.
  • Anticholinergic agents: additive dry‑mouth effect.
  • Other serotonergic drugs (SSRIs, SNRIs): potential for serotonin syndrome.

Frequently Asked Questions

Mitabor Disper contains the antidepressant mirtazapine and is prescribed to treat major depressive disorder in adult patients. It helps improve mood, sleep, and overall functioning by acting on specific brain neurotransmitter pathways.

Mirtazapine blocks presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and antagonizes certain serotonin receptors (5‑HT2, 5‑HT3) while strongly inhibiting H1 histamine receptors. This combined effect enhances noradrenergic and serotonergic signaling, contributing to its antidepressant activity.

The appropriate dose of Mitabor Disper is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and tolerability. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for mirtazapine in pregnancy and lactation are limited. The prescriber must weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss treatment options with their doctor.

To request Mitabor Disper, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mirtazapine belongs to the NaSSA class, differing from SSRIs and SNRIs by its dual antagonism of α2‑adrenergic and specific serotonin receptors, plus strong H1 antihistamine activity. This profile often results in pronounced sedation and appetite increase, which can be advantageous for patients with insomnia or weight loss, but may be less suitable for those concerned about these effects.

Mitabor Disper should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

The medication is taken orally, usually once daily in the evening, with or without food, as directed by the prescriber. Patients should swallow the tablet whole and avoid crushing or chewing unless specifically instructed.

Serious risks include the potential for agranulocytosis or severe neutropenia, hypersensitivity reactions such as Stevens‑Johnson syndrome, seizures, and the emergence or worsening of suicidal thoughts, particularly during the initial weeks of therapy. Prompt medical attention is required if any of these occur.

Mitabor Disper is contraindicated in patients with known hypersensitivity to mirtazapine or any of its excipients. It should also be avoided in individuals currently taking monoamine oxidase inhibitors (MAOIs) or those with severe hepatic impairment without appropriate medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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