Product image of Mitabor Disper (Mirtazapine) supplied by GNH India

Mitabor Disper

Active Ingredient:
Mirtazapine
Origin:
EU

Mitabor Disper (Mirtazapine)

Mirtazapine, the active ingredient in Mitabor Disper, is a NaSSA (noradrenergic and specific serotonergic antidepressant) presented as an oral tablet for oral use. It is indicated for the treatment of major depressive disorder in adult patients, where it can help improve mood, sleep quality, and appetite, and is often chosen for its dual noradrenergic and serotonergic activity. The formulation complies with European Union quality standards and is manufactured under strict Good Manufacturing Practice guidelines.

GNH India supplies Mitabor Disper as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ratiopharm Gmbh

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Indications & Clinical Uses

Mirtazapine acts on noradrenergic and serotonergic pathways and is primarily used for depressive disorders.

  • Major depressive disorder: alleviates depressive symptoms and improves sleep and appetite in adults.
  • Treatment‑resistant depression: used as an adjunct when first‑line antidepressants are insufficient.
  • Depression with prominent anxiety: helps reduce anxiety symptoms associated with depressive episodes.

How It Works

  • Mirtazapine blocks central presynaptic α2‑adrenergic receptors, increasing norepinephrine release, and antagonizes postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic transmission. It also blocks histamine H1 receptors, contributing to its sedative and appetite‑stimulating effects. These combined actions raise noradrenergic and serotonergic neurotransmission, which underlies its antidepressant efficacy.

Side Effects

Mirtazapine may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Sedation
  • Increased appetite leading to weight gain
  • Dry mouth
  • Constipation
  • Dizziness
  • Orthostatic hypotension

Serious or Rare Side Effects

  • Agranulocytosis
  • Severe neutropenia
  • Suicidal thoughts or behavior
  • Hepatic dysfunction
  • Severe hypersensitivity reactions
  • Seizures

Precautions & Warnings

When prescribing Mirtazapine, clinicians should consider several safety precautions.

  • Assess hepatic function: evaluate liver enzymes before initiating therapy.
  • Monitor weight: anticipate possible weight gain and counsel patients.
  • Caution in elderly: increased risk of sedation and falls.
  • Avoid abrupt discontinuation: taper dose to reduce withdrawal symptoms.
  • Use cautiously in bipolar disorder: may precipitate mania.
  • Store at room temperature: keep in original container, protect from moisture.

Avoid Interactions

Mirtazapine can interact with other medicines, affecting its safety and effectiveness.

Major Interactions (Avoid)

  • MAO inhibitors: concurrent use can cause serotonin syndrome.
  • CNS depressants (e.g., benzodiazepines, opioids): may enhance sedation and respiratory depression.
  • Strong CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increase mirtazapine plasma levels.

Moderate Interactions (Monitor Closely)

  • Other serotonergic agents (e.g., SSRIs, SNRIs): monitor for serotonin syndrome.
  • Anticholinergic drugs: additive dry mouth and constipation.
  • Warfarin: may alter INR, require monitoring.
  • Alcohol: can increase sedation and impair coordination.
  • Diuretics: may increase risk of hyponatremia.

Frequently Asked Questions

Mitabor Disper is a generic formulation of mirtazapine indicated for the treatment of major depressive disorder in adult patients. It helps improve mood, sleep quality, and appetite by modulating noradrenergic and serotonergic neurotransmission.

Mirtazapine works by blocking presynaptic α2‑adrenergic receptors, which increases norepinephrine release, and by antagonising postsynaptic 5‑HT2 and 5‑HT3 receptors, enhancing serotonergic activity. Histamine H1 receptor blockade also contributes to its sedative and appetite‑stimulating effects.

The appropriate dose of Mitabor Disper is determined by the prescribing clinician based on the individual’s clinical condition, response, and tolerability. Physicians typically start with a low dose and may adjust it as needed; exact dosing regimens are not provided here.

Safety data for mirtazapine during pregnancy and lactation are limited. Prescribers must weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing women.

To order Mitabor Disper, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with selective serotonin reuptake inhibitors (SSRIs), mirtazapine has a distinct receptor profile that often results in stronger sedative and appetite‑stimulating effects, making it useful for patients with insomnia or weight loss. It may be chosen when SSRIs are ineffective or poorly tolerated.

Store Mitabor Disper at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Mitabor Disper is taken orally as a tablet. Patients should swallow the tablet whole with water, preferably in the evening due to its sedative effect, unless otherwise directed by the prescriber.

Serious risks include agranulocytosis, severe neutropenia, suicidal thoughts or behaviors, hepatic dysfunction, severe hypersensitivity reactions, and seizures. Patients should seek immediate medical attention if they experience signs of infection, jaundice, severe rash, or new psychiatric symptoms.

Mitabor Disper should be avoided in individuals with known hypersensitivity to mirtazapine, those currently taking monoamine oxidase inhibitors, patients with severe hepatic impairment, and anyone for whom the risk–benefit profile is unfavorable as determined by a qualified healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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