Mitomycin 20 mg Inj (Mitomycin Injection) 20 MG

Mitomycin 20 mg Injection is a prescription antineoplastic medication classified as an antitumor antibiotic. It functions as an alkylating agent that inhibits DNA synthesis in cancer cells by producing DNA cross-links. This medication is administered by healthcare professionals via intravenous or intravesical routes depending on the target condition.

Strength

20 MG

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Indications & Clinical Uses

Mitomycin 20 mg Injection is primarily indicated for the palliative treatment of disseminated gastric adenocarcinoma and pancreatic adenocarcinoma, typically in combination with other chemotherapeutic agents. It is also widely utilized via intravesical administration for the management of superficial bladder tumors.

Side Effects

Common side effects of Mitomycin 20 mg Injection include bone marrow suppression (such as leukopenia and thrombocytopenia), nausea, vomiting, alopecia, and fatigue. Serious adverse reactions can include hemolytic uremic syndrome (HUS), pulmonary toxicity, and severe local tissue necrosis if extravasation occurs during intravenous administration.

Precautions & Warnings

Patients receiving Mitomycin 20 mg Injection require close monitoring of hematological parameters, renal function, and pulmonary status. Due to its classification as Pregnancy Category D, it can cause fetal harm and should not be administered to pregnant women. It is contraindicated in patients with a history of hypersensitivity, coagulation disorders, or severe bone marrow depression.

Avoid Interactions

Mitomycin can interact with other myelosuppressive therapies, potentially compounding bone marrow toxicity. Concurrent administration with vinca alkaloids may increase the risk of acute respiratory distress and pulmonary toxicity. Always consult a healthcare professional regarding potential drug interactions with concurrent medications.

Frequently Asked Questions

Mitomycin 20 mg Injection is primarily used as palliative chemotherapy for gastric adenocarcinoma and pancreatic adenocarcinoma. It is also administered intravesically to treat superficial bladder cancer.

This medication is administered by qualified healthcare professionals either intravenously (into a vein) for systemic cancers or intravesically (directly into the bladder) for localized bladder tumors.

Serious risks include severe bone marrow suppression, hemolytic uremic syndrome (HUS), pulmonary toxicity, and local tissue damage or necrosis if the injection leaks outside the vein (extravasation).

No, Mitomycin is classified as Pregnancy Category D and can cause significant fetal harm. Effective contraception is recommended for both male and female patients during and after treatment.

Regular blood counts, renal function tests, and pulmonary monitoring are essential. Patients should immediately report any signs of infection, unusual bruising, bleeding, or shortness of breath to their doctor.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 17 Jun 2026

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