Product image of Mixamin Glucos (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Mixamin Glucos

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Mixamin Glucos (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredient in Mixamin Glucos, is an amino acid solution presented as an intravenous solution for intravenous use. It provides essential amino acids to support the nutritional needs of patients who cannot receive enteral feeding, such as those on parenteral nutrition.
GNH India supplies Mixamin Glucos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Mixamin Glucos is used in clinical settings where parenteral nutrition is required to meet patients' amino acid needs.

  • Surgical patients requiring total parenteral nutrition: supplies essential amino acids to maintain protein synthesis during postoperative recovery.
  • Critically ill patients with catabolic stress: helps preserve lean body mass and supports metabolic demands.
  • Patients with gastrointestinal failure or obstruction: provides a complete amino acid profile when oral or enteral routes are unavailable.

How It Works

  • Mixamin Glucos delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing the gastrointestinal tract. The amino acids serve as substrates for protein synthesis, support nitrogen balance, and replenish depleted pools required for tissue repair, immune function, and metabolic processes. By restoring amino acid availability, the solution helps maintain cellular function in patients unable to ingest nutrients orally.

Side Effects

Mixamin Glucos may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Infusion site erythema or pain: mild irritation at the catheter site.
  • Transient hyperglycemia: elevation of blood glucose during infusion.
  • Electrolyte disturbances: mild shifts in potassium or sodium levels.
  • Nausea or mild gastrointestinal discomfort.
  • Headache or dizziness during administration.
  • Low‑grade fever: temporary rise in body temperature.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe hypersensitivity requiring immediate medical intervention.
  • Severe hypernatremia: marked increase in serum sodium.
  • Metabolic acidosis: significant acid‑base imbalance.
  • Acute renal dysfunction: impaired kidney function in susceptible patients.
  • Sepsis related to catheter contamination.
  • Severe electrolyte imbalance leading to cardiac arrhythmia.

Precautions & Warnings

When using Mixamin Glucos, clinicians should observe several safety measures.

  • Assess renal function: ensure adequate clearance before initiating therapy.
  • Monitor electrolytes: check serum potassium, sodium, and calcium regularly.
  • Check for hypersensitivity: observe for signs of allergic reaction during the first infusion.
  • Adjust dosing in hepatic impairment: reduce infusion rate if liver function is compromised.
  • Avoid in patients with inborn errors of amino acid metabolism: contraindicated in known metabolic disorders.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mixamin Glucos can interact with other medications that affect electrolyte or nitrogen balance.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium chloride: may precipitate severe hyperkalemia.
  • Co‑administration with other amino acid solutions: risk of excessive nitrogen load.

Moderate Interactions (Monitor Closely)

  • Use with loop diuretics: may exacerbate electrolyte shifts; monitor levels.
  • Concurrent insulin therapy: glucose monitoring required due to potential hyperglycemia.
  • Combination with nephrotoxic agents: increased risk of renal impairment; assess kidney function.
  • Interaction with corticosteroids: may alter protein catabolism; observe nutritional status.

Frequently Asked Questions

Mixamin Glucos is an intravenous amino acid solution used to meet the nutritional requirements of patients who cannot receive food or nutrients through the gastrointestinal tract. It is commonly employed in total parenteral nutrition to provide essential amino acids for protein synthesis, tissue repair, and metabolic support in surgical, critical‑care, and gastrointestinal‑failure settings.

The blend supplies a complete profile of essential and non‑essential amino acids directly into the bloodstream. These amino acids act as building blocks for new proteins, help maintain nitrogen balance, and support cellular functions such as immune response and wound healing. By bypassing the digestive system, the solution ensures rapid availability of nutrients for patients who are unable to ingest or absorb them orally.

The prescribed dose of Mixamin Glucos is determined by the treating physician based on the patient’s weight, clinical condition, renal and hepatic function, and overall nutritional goals. Dosing is individualized and adjusted according to laboratory monitoring and therapeutic response, following standard parenteral nutrition protocols.

Safety data for Mixamin Glucos in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Clinicians should evaluate each case carefully and consider alternative nutritional strategies when appropriate.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After receiving the request, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain logistics if needed), and any required import documentation.

Mixamin Glucos offers a balanced mixture of ten essential amino acids, matching the profile of many standard commercial amino acid formulations. Compared with some alternatives that may contain additional non‑essential amino acids or proprietary blends, Mixamin Glucos focuses on the core essential components required for protein synthesis, providing a straightforward option for clinicians seeking a well‑characterized amino acid source.

Mixamin Glucos must be stored refrigerated at 2‑8 °C. Keep the solution in its original container, protect it from light, and avoid freezing or shaking. Before administration, allow the product to reach room temperature if required by the infusion protocol, and inspect for any particulate matter or discoloration.

The solution is administered intravenously, typically via a central venous catheter or a peripheral line, as part of a total parenteral nutrition regimen. Infusion rates are calculated by the prescribing clinician and may be delivered continuously over 24 hours or in intermittent sessions, depending on the patient’s nutritional plan and clinical status.

Serious risks include anaphylactic reactions, severe electrolyte disturbances such as hypernatremia, metabolic acidosis, acute renal dysfunction, and catheter‑related infections leading to sepsis. Patients should be closely monitored for signs of hypersensitivity, changes in renal function, and electrolyte imbalances throughout the infusion.

Mixamin Glucos is contraindicated in individuals with known hypersensitivity to any of its amino acid components, as well as patients with inborn errors of amino acid metabolism (e.g., phenylketonuria). It should also be used with caution in patients with severe renal or hepatic impairment, and in those with uncontrolled electrolyte disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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