Product image of Mixor (Telmisartan, Amlodipine Besilate) supplied by GNH India

Mixor

Active Ingredient:
Telmisartan, Amlodipine Besilate
Origin:
EU

Mixor (Telmisartan, Amlodipine Besilate)

Telmisartan, the active ingredient in Mixor, is a angiotensin II receptor blocker and calcium channel blocker presented as a tablet for oral use. It treats hypertension in adult patients.
GNH India supplies Mixor as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Mixor combines an angiotensin II receptor blocker with a calcium channel blocker to lower elevated blood pressure.

  • Essential hypertension: provides additive blood pressure reduction.
  • Stage 1 hypertension: helps achieve target systolic and diastolic values.
  • Stage 2 hypertension: offers enhanced control when monotherapy is insufficient.

How It Works

  • Telmisartan selectively blocks the AT1 receptor for angiotensin II, preventing vasoconstriction and aldosterone release. Amlodipine besilate inhibits L-type calcium channels in vascular smooth muscle, causing vasodilation. The complementary actions produce an additive reduction in systemic vascular resistance and arterial pressure.

Side Effects

Mixor may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Dizziness: transient light‑headedness, especially after the first dose.
  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of ankles or feet.
  • Flushing: warm sensation and reddening of skin.
  • Fatigue: general tiredness.
  • Nausea: mild stomach upset.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or airway requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure leading to fainting or shock.
  • Hepatic injury: abnormal liver function tests.
  • Myocardial infarction: rare occurrence of heart attack.

Precautions & Warnings

Before initiating Mixor, clinicians should evaluate patient‑specific factors and monitor for potential risks.

  • Monitor blood pressure: adjust therapy based on response.
  • Assess renal function: check creatinine and electrolytes periodically.
  • Caution in hepatic impairment: use only if benefits outweigh risks.
  • Elderly patients: start at lower dose and monitor for hypotension.
  • Avoid strong CYP3A4 inhibitors: may increase amlodipine levels.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mixor can interact with several drug classes; awareness of the interaction level guides clinical decisions.

Major Interactions (Avoid)

  • ACE inhibitors or aliskiren in diabetic patients: risk of hyperkalemia and renal dysfunction.
  • Potassium‑sparing diuretics: may cause dangerous hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase amlodipine exposure.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect.
  • Simvastatin: increased risk of statin‑related myopathy.
  • Digoxin: may require serum level monitoring.

Frequently Asked Questions

Mixor is an oral combination of telmisartan and amlodipine besilate indicated for the treatment of hypertension. The two agents work together to lower blood pressure by blocking angiotensin II‑mediated vasoconstriction and relaxing vascular smooth muscle through calcium‑channel inhibition.

Telmisartan selectively blocks the AT1 receptor for angiotensin II, preventing the hormone from causing vasoconstriction and aldosterone release. This results in reduced peripheral resistance and lower blood pressure, complementing the vasodilatory effect of amlodipine.

The dose of Mixor is individualized by the prescribing clinician based on the patient’s blood pressure, response to therapy, and tolerability. Healthcare professionals determine the appropriate strength and dosing schedule for each patient.

Safety of Mixor in pregnancy or lactation has not been established. Telmisartan is generally contraindicated in pregnancy because of fetal toxicity, and amlodipine is used with caution. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Mixor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mixor combines an ARB (telmisartan) with a calcium‑channel blocker (amlodipine), offering additive blood‑pressure reduction compared with monotherapy. This dual‑action approach can improve control in patients who need more than one agent, while potentially reducing pill burden versus taking two separate drugs.

Mixor should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture and direct sunlight to maintain stability throughout its shelf life.

Mixor is taken orally, usually once daily, with or without food. Patients should swallow the tablet whole with a glass of water and follow the dosing instructions provided by their prescriber.

The most serious risks include angioedema, severe hypotension, and hepatic injury. Patients should seek immediate medical attention if they experience swelling of the face, lips, tongue, or difficulty breathing, as well as signs of a sudden drop in blood pressure or liver dysfunction.

Mixor is contraindicated in patients with known hypersensitivity to telmisartan, amlodipine, or any component of the formulation. It should also be avoided in individuals with severe hepatic impairment, and in pregnant women due to the risks associated with telmisartan.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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