Product image of Mixor (Telmisartan, Amlodipine Besilate) supplied by GNH India

Mixor

Active Ingredient:
Telmisartan, Amlodipine Besilate
Origin:
EU

Mixor (Telmisartan, Amlodipine Besilate)

Telmisartan and Amlodipine besilate, the active ingredient in Mixor, is an Angiotensin II receptor blocker; Calcium channel blocker presented as an oral tablet for oral use. It treats hypertension in adult patients. GNH India supplies Mixor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Mixor combines two antihypertensive agents that act on the renin‑angiotensin system and vascular smooth‑muscle calcium channels to lower blood pressure.
  • Hypertension: reduces systolic and diastolic pressure and lowers cardiovascular risk.
  • Essential hypertension: provides sustained blood‑pressure control when monotherapy is insufficient.
  • High‑risk cardiovascular patients: contributes to target‑organ protection alongside lifestyle measures.

How It Works

  • Telmisartan selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release, while amlodipine besilate inhibits calcium influx into vascular smooth‑muscle cells, causing dose‑dependent vasodilation. The combined effect results in reduced peripheral resistance and lowered arterial pressure.

Side Effects

Adverse reactions may occur with any antihypertensive therapy.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Peripheral edema, especially of the ankles
  • Flushing or warmth sensation
  • Fatigue or mild weakness
  • Palpitations

Serious or Rare Side Effects

  • Angioedema involving face, lips, tongue or airway
  • Severe hypotension leading to syncope
  • Hepatic enzyme elevations or liver injury
  • Myocardial infarction or worsening heart failure
  • Life‑threatening arrhythmias
  • Severe allergic reactions such as Stevens‑Johnson syndrome

Precautions & Warnings

  • Patients should be evaluated for specific risk factors before initiating therapy.
  • Monitor blood pressure regularly: adjust dose based on response.
  • Assess renal function: dose may need adjustment in renal impairment.
  • Caution in hepatic impairment: consider lower starting dose.
  • Avoid use in known hypersensitivity to either component.
  • Pregnancy and lactation: consult a physician; use only if benefits outweigh risks.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Drug interactions can affect efficacy or safety and should be reviewed.

Major Interactions (Avoid)

  • Concomitant use with ACE inhibitors or other ARBs: risk of additive hypotension and hyperkalemia.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase amlodipine plasma levels.
  • Lithium: possible increase in lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Diuretics, especially thiazides: may alter electrolyte balance and blood‑pressure response.
  • Simvastatin or other statins metabolized by CYP3A4: increased risk of myopathy; monitor muscle symptoms.

Frequently Asked Questions

Mixor is a prescription oral tablet that combines telmisartan and amlodipine besilate to treat hypertension. The dual mechanism helps lower blood pressure by blocking angiotensin II receptors and relaxing vascular smooth muscle, providing effective control for patients whose blood pressure is not adequately managed with a single agent.

Telmisartan, one of the active ingredients in Mixor, selectively blocks angiotensin II type 1 (AT1) receptors. This inhibition prevents the vasoconstrictive and aldosterone‑secreting effects of angiotensin II, leading to reduced peripheral vascular resistance and lower blood pressure.

The appropriate dose of Mixor is determined by the prescribing healthcare professional based on the individual’s blood‑pressure goals, renal function, and other clinical factors. Patients should follow the exact dosage instructions provided by their prescriber and not adjust the dose on their own.

Safety of Mixor in pregnancy or while breastfeeding has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Mixor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mixor offers a fixed‑dose combination of an angiotensin II receptor blocker and a calcium‑channel blocker, which can simplify therapy compared with taking two separate tablets. This combination may improve adherence and provide additive blood‑pressure reduction, whereas monotherapy with either class alone may be less effective in some patients.

Mixor tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, direct sunlight and heat sources to maintain product stability throughout its shelf life.

Mixor is taken orally, usually once daily, with or without food, as directed by the prescribing clinician. The tablet should be swallowed whole with a full glass of water and not chewed or crushed unless specifically instructed.

Serious risks include angioedema, severe hypotension, liver enzyme elevations, and rare but life‑threatening allergic reactions such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if they experience swelling of the face or throat, persistent dizziness, jaundice, or severe skin rash.

Mixor should be avoided in individuals with known hypersensitivity to telmisartan, amlodipine, or any excipients in the tablet. It is also contraindicated in patients with severe hepatic impairment, and caution is advised in those with renal dysfunction, pregnancy, or concurrent use of certain interacting medications.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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