Product image of Mixtard 30 (Insulin Human) supplied by GNH India

Mixtard 30

Active Ingredient:
Insulin Human
Origin:
EU

Mixtard 30 (Insulin Human)

Insulin human, the active ingredient in Mixtard 30, is an insulin presented as a 100 U/mL premixed injectable solution for subcutaneous use. It is employed to manage blood glucose levels in individuals with type 1 or type 2 diabetes mellitus, providing both basal and prandial insulin action.

GNH India supplies Mixtard 30 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable cold‑chain logistics for this biologic product. These deliveries are made through regulated distribution networks.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

  • Mixtard 30 is an insulin preparation used in the management of diabetes mellitus.
  • Type 1 diabetes mellitus: supplies both basal and rapid‑acting insulin components, helping patients achieve stable blood glucose levels and reduce the risk of hypoglycaemic episodes.
  • Type 2 diabetes mellitus: adds a premixed insulin regimen when diet, exercise, and oral hypoglycaemic agents are insufficient, facilitating improved glycaemic control and simplifying injection schedules.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase activity. This triggers intracellular signaling cascades that promote translocation of GLUT‑4 transporters, increasing glucose uptake, and suppress hepatic gluconeogenesis. The premixed formulation delivers both short‑acting and intermediate‑acting insulin, providing immediate post‑prandial glucose reduction and sustained basal coverage.

Side Effects

Mixtard 30 may be associated with a range of adverse reactions, varying in frequency and severity.

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed or dose is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increase in body weight associated with insulin therapy.
  • Lipodystrophy: localized fat accumulation or loss at injection sites.

Serious or Rare Side Effects

  • Severe hypoglycaemia: seizures or loss of consciousness requiring assistance.
  • Anaphylactic reaction: rare systemic allergic response that may be life‑threatening.
  • Insulin edema: fluid retention leading to peripheral swelling.
  • Hypokalemia: low serum potassium levels in rare cases.

Precautions & Warnings

When using Mixtard 30, several precautions should be observed to ensure safe and effective therapy.

  • Blood glucose monitoring: check levels regularly to adjust dose and avoid hypoglycaemia.
  • Dose adjustment during illness: reduce or increase insulin based on carbohydrate intake and stress.
  • Caution in renal impairment: impaired clearance may increase risk of prolonged insulin action.
  • Use during pregnancy: safety category is unknown; prescribe only if benefits outweigh potential risks.
  • Avoid use in hypoglycaemia: do not administer if patient is already experiencing low blood glucose.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Mixtard 30 can interact with other medicines, altering its glucose‑lowering effect or masking symptoms.

Major Interactions (Avoid)

  • Sulfonylureas: combined use may cause severe hypoglycaemia.
  • Beta‑blockers: may mask typical hypoglycaemia warning signs such as tachycardia.
  • Alcohol: excessive intake can potentiate insulin’s glucose‑lowering action leading to hypoglycaemia.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance insulin sensitivity, increasing hypoglycaemia risk.
  • Corticosteroids: can raise blood glucose, potentially requiring higher insulin doses.
  • Thiazide diuretics: may impair glucose tolerance, necessitating dose adjustments.
  • Oral contraceptives: hormonal changes can affect insulin requirements.

Frequently Asked Questions

Mixtard 30 is a premixed insulin human formulation indicated for the treatment of type 1 and type 2 diabetes mellitus. It provides both rapid‑acting and intermediate‑acting insulin components to help patients achieve and maintain target blood glucose levels as part of a comprehensive diabetes management plan.

Insulin human mimics the action of natural pancreatic insulin. It binds to insulin receptors on muscle, fat and liver cells, activating intracellular pathways that increase glucose uptake, inhibit hepatic glucose production, and promote storage of glucose as glycogen, thereby lowering circulating blood glucose concentrations.

The dose of Mixtard 30 is individualized and set by a qualified prescriber based on factors such as the patient’s age, weight, type of diabetes, current glycaemic control, dietary intake, activity level, and concurrent medications. Regular monitoring of blood glucose guides dose adjustments.

The safety of insulin human in pregnancy and lactation is not fully established; it is generally prescribed only when the expected benefit to the mother outweighs potential risks to the fetus or infant. Healthcare providers should evaluate each case carefully and monitor maternal and fetal health closely.

To order Mixtard 30, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details (including cold‑chain handling) and assists with any required import documentation.

Mixtard 30 is a premixed insulin containing both short‑acting and intermediate‑acting components, offering a simpler injection schedule compared with basal‑bolus regimens that require separate rapid‑acting and long‑acting insulins. While convenient, it provides less flexibility for precise dose titration than basal‑bolus therapy, which may be preferred in patients needing individualized basal and prandial dosing.

Mixtard 30 must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, the vial may be allowed to reach room temperature for a few minutes, but the solution must remain clear and free of particles. Discard any vial that appears discolored or cloudy.

Mixtard 30 is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection site should be rotated with each dose to reduce the risk of lipodystrophy. The exact timing (e.g., before meals) and injection technique are determined by the prescribing clinician based on the patient’s treatment plan.

The most serious risks include severe hypoglycaemia, which can lead to seizures, loss of consciousness or injury, and rare allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of low blood glucose and to seek immediate medical assistance if a severe reaction occurs.

Mixtard 30 should not be used by individuals with a known hypersensitivity to insulin human or any excipients in the formulation. It is also contraindicated in patients experiencing hypoglycaemia at the time of administration. Caution is advised in patients with severe renal or hepatic impairment, and use during pregnancy or lactation should be limited to situations where benefits outweigh risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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