Product image of Mixtard 30 Flexpen (Insulin Human) supplied by GNH India

Mixtard 30 Flexpen

Active Ingredient:
Insulin Human
Origin:
EU

Mixtard 30 Flexpen (Insulin Human)

Insulin human, the active ingredient in Mixtard 30 Flexpen, is an insulin presented as a solution for subcutaneous injection pen device for subcutaneous use. It treats hyperglycemia in patients with diabetes mellitus, including both type 1 and type 2 disease.

GNH India supplies Mixtard 30 Flexpen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

  • Mixtard 30 Flexpen is an insulin preparation used in the management of diabetes mellitus, a disorder of glucose regulation.
  • Type 1 diabetes mellitus: provides basal and prandial insulin to achieve glycemic control.
  • Type 2 diabetes mellitus: supplements endogenous insulin to lower elevated blood glucose levels.
  • Insulin deficiency: replaces missing hormone to maintain normal metabolism.
  • Post‑prandial hyperglycemia: smoothes glucose spikes after meals.
  • Hyperglycemia: reduces overall blood glucose concentrations.

How It Works

  • Insulin human binds to insulin receptors on cell membranes, activating intrinsic tyrosine‑kinase activity. This triggers intracellular signaling cascades that promote translocation of GLUT4 transporters to the cell surface, increase glucose uptake in muscle and adipose tissue, and suppress hepatic gluconeogenesis, thereby lowering circulating glucose levels.

Side Effects

Insulin human may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hypoglycemia: low blood sugar episodes, especially if meals are missed or dose is excessive.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increased appetite and caloric storage.
  • Edema: mild fluid retention, particularly in the lower extremities.

Serious or Rare Side Effects

  • Severe hypoglycemia leading to seizures or loss of consciousness.
  • Anaphylactic or severe allergic reactions, including rash, bronchospasm, or angioedema.
  • Development of insulin antibodies that may alter drug efficacy.

Precautions & Warnings

  • When using Mixtard 30 Flexpen, several safety considerations should be observed.
  • Hypoglycemia risk: monitor blood glucose and adjust dose as needed.
  • Renal impairment: consider dose reduction and close monitoring.
  • Pregnancy: use only if benefits outweigh risks and under medical supervision.
  • Allergic reactions: discontinue if signs of hypersensitivity appear.
  • Injection site rotation: avoid repeated use in same area to prevent lipodystrophy.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mixtard 30 Flexpen can interact with other medicines, affecting glucose control.

Major Interactions (Avoid)

  • Sulfonylureas: combined use may precipitate severe hypoglycemia.
  • Beta‑blockers: can mask hypoglycemia symptoms, requiring careful monitoring.
  • Alcohol: may potentiate insulin’s glucose‑lowering effect, increasing hypoglycemia risk.

Moderate Interactions (Monitor Closely)

  • Thiazide diuretics: may raise blood glucose, necessitating dose adjustment.
  • Corticosteroids: can increase insulin requirements, requiring close observation.
  • ACE inhibitors: may enhance insulin sensitivity, potentially leading to lower glucose levels.

Frequently Asked Questions

Mixtard 30 Flexpen is a premixed insulin formulation indicated for the control of blood glucose in adults with type 1 or type 2 diabetes mellitus. It provides both rapid‑acting and intermediate‑acting insulin components to cover mealtime spikes and basal needs.

Insulin human mimics the body’s natural insulin by binding to insulin receptors on muscle, fat and liver cells. This activates intracellular pathways that increase glucose uptake, promote glycogen synthesis, and suppress hepatic glucose production, thereby lowering circulating blood‑sugar levels.

The dose is individualized by the prescribing healthcare professional based on factors such as the patient’s current blood‑glucose readings, carbohydrate intake, body weight, renal function, and overall treatment goals. Patients should follow the prescriber’s instructions and adjust only under medical guidance.

Insulin is generally considered the treatment of choice for diabetes in pregnancy because it does not cross the placenta in significant amounts. However, use of Mixtard 30 Flexpen should be under strict medical supervision, and the benefits must outweigh any potential risks. Breastfeeding mothers should also consult their clinician.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Mixtard 30 Flexpen is a premixed insulin containing 30% rapid‑acting and 70% intermediate‑acting components, offering a convenient single‑injection regimen for many patients. Compared with basal‑only insulins, it provides prandial coverage, but it is less flexible than basal‑bolus regimens that use separate rapid‑acting and long‑acting products.

Store the pen at 2‑8 °C (refrigerated) in its original carton, protected from light. Do not freeze or shake the device. Once in use, it may be kept at room temperature (up to 30 °C) for a maximum of 28 days, after which it should be discarded.

The pen is designed for subcutaneous injection. After selecting the prescribed dose, the user inserts a new needle, primes the pen if required, and injects into the abdomen, thigh, or upper arm at a 90° angle. Injection sites should be rotated to reduce lipodystrophy risk.

The most critical risk is severe hypoglycemia, which can cause confusion, seizures, or loss of consciousness. Allergic reactions, including anaphylaxis, are rare but require immediate medical attention. Persistent unexplained weight gain or edema may also signal the need for dose reassessment.

Patients with a known hypersensitivity to insulin human or any excipients in the formulation should avoid its use. It is also contraindicated in individuals experiencing hypoglycemia until the condition is resolved, and in those for whom a different insulin regimen is clinically more appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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