Product image of Mixtard 30 Flexpen (Insulin Human) supplied by GNH India

Mixtard 30 Flexpen

Active Ingredient:
Insulin Human
Origin:
EU

Mixtard 30 Flexpen (Insulin Human)

Insulin human, the active ingredient in Mixtard 30 Flexpen, is an insulin presented as an injectable solution (Flexpen) for subcutaneous use. It mimics the action of endogenous pancreatic insulin, facilitating the uptake of glucose into muscle and adipose tissue while suppressing hepatic glucose production. The product is indicated for the management of hyperglycaemia in both type 1 and type 2 diabetes mellitus.

GNH India supplies Mixtard 30 Flexpen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Mixtard 30 Flexpen, an insulin formulation that combines rapid‑acting and intermediate‑acting components, is employed in the therapeutic management of diabetes mellitus to regulate blood glucose levels.

  • Type 1 diabetes mellitus: supplies both basal and mealtime insulin to mimic physiological insulin patterns, helping patients achieve target glycaemic levels.
  • Type 2 diabetes mellitus: provides supplemental insulin to overcome insulin resistance and insufficient endogenous secretion, supporting overall glucose control.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor’s intrinsic tyrosine kinase activity. This triggers intracellular signaling cascades that promote translocation of GLUT‑4 transporters to the cell membrane, increasing glucose uptake, and suppresses hepatic gluconeogenesis. The combined rapid‑acting and intermediate‑acting profile of Mixtard 30 Flexpen provides both post‑prandial and basal insulin coverage.

Side Effects

Like all insulin preparations, Mixtard 30 Flexpen may be associated with adverse reactions at the injection site and systemic effects.

Common Side Effects

  • Hypoglycaemia: low blood glucose episodes, especially if meals are missed or activity is increased.
  • Injection site pain or bruising.
  • Lipodystrophy: localized fat accumulation or loss at injection sites.
  • Weight gain: due to improved glucose utilization.
  • Mild allergic rash or itching.
  • Peripheral oedema.

Serious or Rare Side Effects

  • Severe hypoglycaemia with neuroglycopenic symptoms.
  • Anaphylactic reaction or systemic insulin allergy.
  • Hypokalemia: low potassium levels.
  • Acute pancreatitis.
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Severe injection‑site infection.

Precautions & Warnings

When using Mixtard 30 Flexpen, clinicians and patients should observe several safety measures.

  • Dose individualisation: adjust the dose based on regular blood‑glucose monitoring and clinical response.
  • Hypoglycaemia risk: educate patients on recognising and treating low glucose episodes.
  • Renal impairment: monitor closely as reduced renal function may prolong insulin action.
  • Pregnancy and lactation: use only if the anticipated benefit outweighs potential risk.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mixtard 30 Flexpen can interact with other medicines that affect glucose metabolism or mask hypoglycaemia.

Major Interactions (Avoid)

  • Concurrent sulfonylureas: may precipitate severe hypoglycaemia.
  • Beta‑blockers: can blunt typical hypoglycaemia warning signs.
  • Systemic corticosteroids: may increase insulin requirements markedly.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance insulin sensitivity, requiring glucose monitoring.
  • Thiazide diuretics: can raise blood glucose, necessitating dose adjustment.
  • Oral contraceptives: may alter insulin needs, warranting closer observation.

Frequently Asked Questions

Mixtard 30 Flexpen is a premixed insulin preparation used to control high blood‑glucose levels in adults with type 1 or type 2 diabetes mellitus. It provides both rapid‑acting insulin for meals and intermediate‑acting insulin for basal coverage, helping patients achieve target glycaemic control as part of a comprehensive diabetes management plan.

Insulin human is a recombinant form of human insulin that binds to insulin receptors on muscle, fat and liver cells. This binding activates intracellular pathways that move glucose‑transport proteins to the cell surface, allowing glucose to enter cells for energy use or storage, while simultaneously suppressing the liver’s production of new glucose.

The dose of Mixtard 30 Flexpen is individualized by the prescribing healthcare professional. It is based on factors such as the patient’s current blood‑glucose readings, dietary habits, physical activity, renal function and overall response to therapy. Patients should follow the prescriber’s instructions and adjust only under medical guidance.

Data on the use of insulin human in pregnancy and lactation are limited. Insulin is generally considered the preferred glucose‑lowering therapy when needed during pregnancy, but the decision should be made by the treating physician after weighing potential benefits against any unknown risks. Breastfeeding mothers should consult their doctor before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain handling where required—and assistance with import documentation.

Mixtard 30 Flexpen is a premixed insulin that combines rapid‑acting and intermediate‑acting components in a fixed 30%/70% ratio. Compared with basal‑only insulins, it offers both mealtime and background coverage in a single injection, reducing injection frequency. Unlike separate rapid‑acting and basal pens, dose flexibility between the two components is limited, which may be advantageous for patients preferring simplicity.

The Flexpen should be stored in a refrigerator at 2 °C to 8 °C (36 °F to 46 °F). Keep it in the original packaging, protect it from light, and avoid freezing. Once in use, the pen may be kept at controlled room temperature (up to 30 °C) for up to 28 days, but it must never be shaken vigorously.

Mixtard 30 Flexpen is administered subcutaneously using the built‑in pen mechanism. The injection sites include the abdomen, thigh, upper arm or buttock, rotating sites with each dose. Patients should clean the skin with an alcohol swab, attach a new needle, set the prescribed dose, and inject at a 90‑degree angle, following the pen’s instructions.

The most serious risks include severe hypoglycaemia, which can cause confusion, loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Rare but serious events such as hypokalemia, acute pancreatitis or severe injection‑site infections have also been reported. Prompt medical attention is required if any of these occur.

Mixtard 30 Flexpen should not be used by individuals with a known hypersensitivity to insulin human or any of the pen’s excipients. It is also contraindicated in patients with severe hypoglycaemia unawareness who cannot recognize low‑glucose symptoms, and in those with certain endocrine disorders where insulin therapy is inappropriate without specialist supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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