Product image of Mixtard 30 Innolet (Insulin Human) supplied by GNH India

Mixtard 30 Innolet

Active Ingredient:
Insulin Human
Origin:
EU

Mixtard 30 Innolet (Insulin Human)

Insulin Human, the active ingredient in Mixtard 30 Innolet, is an insulin presented as a premixed insulin suspension for subcutaneous injection use. It lowers blood glucose by facilitating cellular uptake and suppressing hepatic glucose production, and is indicated for the management of type 1 and type 2 diabetes mellitus.

GNH India supplies Mixtard 30 Innolet as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for importers globally.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Mixtard 30 Innolet is a premixed insulin used in the management of diabetes mellitus, a disorder of glucose regulation.

  • Type 1 diabetes mellitus: provides basal and prandial insulin to achieve glycemic control.
  • Type 2 diabetes mellitus: supplements oral agents or diet/exercise when additional glucose lowering is required.
  • Acute hyperglycemia: rapidly reduces elevated blood glucose during uncontrolled diabetic episodes.

How It Works

  • Insulin Human binds to insulin receptors on muscle, adipose and hepatic cells, activating the receptor tyrosine kinase pathway. This promotes translocation of GLUT4 transporters, enhancing glucose uptake, while simultaneously inhibiting hepatic gluconeogenesis and glycogenolysis. The premixed formulation combines short‑acting and intermediate‑acting insulin fractions to deliver both mealtime and basal insulin coverage.

Side Effects

Mixtard 30 Innolet may be associated with a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Hypoglycemia: symptoms of low blood sugar such as sweating, tremor, or confusion.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: modest increase in body weight due to improved glucose utilization.
  • Lipodystrophy: localized changes in subcutaneous fat with repeated injections.

Serious or Rare Side Effects

  • Severe hypoglycemia: can lead to loss of consciousness or seizures.
  • Allergic reactions: including rash, urticaria, or anaphylaxis.
  • Insulin edema: fluid retention causing swelling, particularly in the lower extremities.

Precautions & Warnings

When using Mixtard 30 Innolet, several precautions should be observed to ensure safe and effective therapy.

  • Dose adjustment: tailor the dose based on regular blood glucose monitoring and individual response.
  • Hypoglycemia risk: educate patients on early signs and appropriate treatment measures.
  • Renal impairment: monitor renal function closely as insulin clearance may be reduced.
  • Pregnancy: consider use only if the potential benefit outweighs the potential risk to the fetus.
  • Drug interactions: review all concomitant medications for possible additive glucose‑lowering effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Mixtard 30 Innolet can interact with other medicines, altering its glucose‑lowering effect or masking symptoms.

Major Interactions (Avoid)

  • Beta‑blockers: may mask the adrenergic signs of hypoglycemia.
  • MAO inhibitors: can potentiate insulin‑induced hypoglycemia.

Moderate Interactions (Monitor Closely)

  • Oral hypoglycemics (e.g., sulfonylureas, meglitinides): additive glucose‑lowering effect may increase hypoglycemia risk.
  • Thiazide diuretics: may raise blood glucose levels, requiring dose adjustment.
  • Corticosteroids: can reduce insulin efficacy, necessitating closer monitoring.

Frequently Asked Questions

Mixtard 30 Innolet is a premixed insulin human formulation indicated for the treatment of type 1 and type 2 diabetes mellitus. It provides both basal and mealtime insulin coverage to help patients achieve target blood glucose levels as part of a comprehensive diabetes management plan.

Insulin Human binds to insulin receptors on muscle, fat and liver cells, activating intracellular signaling that promotes glucose uptake via GLUT4 transporters and suppresses hepatic glucose production. The combined short‑acting and intermediate‑acting components in Mixtard 30 Innolet deliver rapid post‑prandial control together with longer‑lasting basal insulin effects.

The dose of Mixtard 30 Innolet is individualized. A qualified prescriber determines the total daily insulin requirement based on the patient’s blood glucose readings, diet, activity level and other medications. The dose may be adjusted over time to maintain optimal glycemic control while minimizing the risk of hypoglycemia.

Safety data for Insulin Human in pregnancy and lactation are limited, and the product’s pregnancy category is listed as unknown. It should be used during pregnancy or while breastfeeding only if the potential benefits justify any potential risk to the fetus or infant, and under close medical supervision.

To place an order, submit an enquiry on the Mixtard 30 Innolet product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details (including cold‑chain logistics) and any necessary import documentation.

Mixtard 30 Innolet is a premixed insulin containing a fixed ratio of short‑acting and intermediate‑acting insulin human, offering convenience compared with separate basal and bolus injections. Compared with rapid‑acting analogues, it may have a slightly slower onset but provides a predictable basal component, making it suitable for patients who prefer fewer daily injections.

Store Mixtard 30 Innolet refrigerated at 2‑8 °C (36‑46 °F). Protect the vial from direct light and do not freeze. Before use, gently roll the vial to mix the suspension; do not shake vigorously. Once opened, the product may be kept at controlled room temperature (up to 25 °C) for a limited period as indicated on the label.

Mixtard 30 Innolet is administered by subcutaneous injection, typically into the abdomen, thigh or upper arm. The injection should be given at a 90‑degree angle using a suitable needle, rotating sites with each dose to reduce the risk of lipodystrophy. Patients should be instructed on proper technique and disposal of sharps.

The most serious risks include severe hypoglycemia, which can cause loss of consciousness or seizures, and allergic reactions ranging from rash to anaphylaxis. Insulin edema and cardiovascular events may also occur, particularly in patients with pre‑existing heart disease. Prompt medical attention is required if any of these serious reactions are suspected.

Mixtard 30 Innolet is contraindicated in individuals with a known hypersensitivity to insulin human, any of the excipients in the formulation, or a history of severe allergic reactions to insulin products. It should also be avoided in patients with hypoglycemia unawareness unless closely monitored by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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