Product image of Mixtard 50 Penfill (Insulin Human) supplied by GNH India

Mixtard 50 Penfill

Active Ingredient:
Insulin Human
Origin:
EU

Mixtard 50 Penfill (Insulin Human)

Insulin human, the active ingredient in Mixtard 50 Penfill, is an insulin presented as a pre‑filled pen for subcutaneous use. It lowers blood glucose by replacing deficient endogenous insulin in individuals with type 1 or type 2 diabetes mellitus and is used under medical supervision to achieve glycaemic control.

GNH India supplies Mixtard 50 Penfill as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory‑aligned distribution, and technical support for diabetes care programs across multiple regions.

Manufacturer / TM Owner

Novo Nordisk A/S

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Indications & Clinical Uses

Mixtard 50 Penfill contains insulin human, an antidiabetic agent that replaces endogenous insulin to control blood glucose.

  • Type 1 diabetes mellitus: provides required insulin to maintain glycaemic control.
  • Type 2 diabetes mellitus: supplements endogenous insulin to improve glucose regulation.
  • Pre‑meal hyperglycemia: helps achieve post‑prandial glucose targets when combined with meals.
  • Basal insulin requirement: delivers basal insulin coverage as part of a basal‑bolus regimen.
  • Gestational diabetes mellitus: may be used under specialist supervision to control maternal glucose levels.

How It Works

  • Insulin human binds to insulin receptors on muscle, adipose and hepatic cells, activating intracellular signaling pathways that increase glucose uptake, promote glycogen synthesis, and suppress hepatic glucose production, thereby reducing circulating blood‑glucose concentrations.

Side Effects

Adverse reactions may occur with insulin therapy and should be monitored.

Common Side Effects

  • Hypoglycemia: symptoms such as sweating, tremor, or confusion.
  • Injection site reactions: redness, swelling, or itching at the injection site.
  • Weight gain: increase in body weight associated with insulin therapy.
  • Lipodystrophy: localized fat accumulation or loss at injection sites.

Serious or Rare Side Effects

  • Severe hypoglycemia: loss of consciousness or seizures requiring emergency care.
  • Anaphylactic reaction: difficulty breathing, swelling of face or throat.
  • Insulin antibodies: may cause unpredictable glucose control.

Precautions & Warnings

When using Mixtard 50 Penfill, several safety considerations are recommended.

  • Hypoglycemia risk: monitor blood glucose regularly and adjust dose as needed.
  • Dose adjustments: required when changing diet, physical activity, or concomitant medications.
  • Renal impairment: may need lower dose and close monitoring of glucose.
  • Pregnancy and lactation: use only if benefits outweigh potential risks to mother and fetus.
  • Drug interactions: avoid or monitor use with sulfonylureas, beta‑blockers, and other hypoglycemic agents.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Insulin human can interact with several drug classes, influencing glucose control.

Major Interactions (Avoid)

  • Sulfonylureas: combined use can cause severe hypoglycemia.
  • Beta‑blockers: may mask hypoglycemia symptoms, requiring careful monitoring.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance insulin’s glucose‑lowering effect.
  • Thiazide diuretics: can increase blood glucose levels, necessitating dose review.
  • Corticosteroids: may raise insulin requirements, requiring dose adjustment.

Frequently Asked Questions

Mixtard 50 Penfill is a pre‑filled insulin pen that provides insulin human to replace deficient endogenous insulin. It is prescribed to help individuals with type 1 or type 2 diabetes achieve and maintain target blood‑glucose levels as part of a comprehensive diabetes management plan.

Insulin human mimics the action of natural human insulin. After subcutaneous injection, it binds to insulin receptors on muscle, fat and liver cells, triggering pathways that increase glucose uptake, promote glycogen storage, and suppress hepatic glucose production, thereby lowering circulating glucose concentrations.

The dose of Mixtard 50 Penfill is individualized. A qualified prescriber calculates the required units based on the patient’s current blood‑glucose readings, body weight, diet, activity level, and any concurrent medications. The prescriber then provides a specific dosing regimen that the patient follows.

Insulin is generally considered the preferred glucose‑lowering therapy during pregnancy because it does not cross the placenta in significant amounts. However, Mixtard 50 Penfill should be used only when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Mixtard 50 Penfill, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping options and any necessary import documentation.

Mixtard 50 Penfill contains human insulin, which has a rapid onset and short duration compared with some long‑acting analogues. It is suitable for basal‑bolus regimens and offers flexibility in dose titration. Compared with insulin analogues, it may be less expensive but requires careful timing around meals to avoid hypoglycemia.

Mixtard 50 Penfill must be stored in a refrigerator at 2‑8 °C. Keep the pen in its original carton, protect it from light, and do not freeze or shake the device. Once in use, most pens can be kept at controlled room temperature (up to 30 °C) for a limited number of days, as indicated on the label.

Mixtard 50 Penfill is administered by subcutaneous injection. The user selects the prescribed dose on the pen’s dial, attaches a new needle, and injects into a fatty tissue area such as the abdomen, thigh or upper arm. Proper technique, rotation of injection sites and disposal of used needles are essential for safety.

The most serious risks include severe hypoglycemia, which can lead to loss of consciousness or seizures, and rare allergic reactions such as anaphylaxis. Patients should be educated to recognize early signs of hypoglycemia, monitor glucose frequently, and seek immediate medical attention if a severe reaction occurs.

Mixtard 50 Penfill should be avoided in individuals with a known hypersensitivity to insulin human or any excipients in the formulation. It is also contraindicated in patients experiencing hypoglycemia at the time of administration. Clinicians should assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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