Product image of Mizocler (Mizolastine) supplied by GNH India

Mizocler

Active Ingredient:
Mizolastine
Origin:
EU

Mizocler (Mizolastine)

Mizolastine, the active ingredient in Mizocler, is an antihistamine presented as an oral tablet for oral administration. It selectively blocks peripheral H1‑receptors, thereby reducing histamine‑mediated symptoms such as sneezing, itching, and rash in patients with allergic rhinitis or chronic urticaria and are commonly prescribed for seasonal and perennial forms of the disease, providing symptomatic relief and improving quality of life.

GNH India supplies Mizocler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory conformity across markets.

Manufacturer / TM Owner

Desma Pharma

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Indications & Clinical Uses

Mizocler (mizolastine) is employed in the treatment of allergic disorders mediated by histamine activation, primarily targeting conditions of the upper respiratory tract and the skin where histamine release causes discomfort.

  • Allergic rhinitis: relieves nasal congestion, sneezing, itching and watery eyes associated with seasonal or perennial allergic rhinitis.
  • Chronic urticaria: reduces the number and intensity of hives and associated itching in patients with persistent urticaria.

How It Works

  • Mizolastine acts as a selective peripheral H1‑receptor antagonist. By binding to the H1 histamine receptor on mast cells, basophils and other target tissues, it prevents histamine from triggering the intracellular signaling cascade that leads to vasodilation, increased vascular permeability, and sensory nerve activation. This blockade reduces typical allergic symptoms while largely sparing central nervous system receptors, limiting sedation.

Side Effects

Mizocler may be associated with a range of adverse reactions, varying from mild and transient to rare but serious.

Common Side Effects

  • Drowsiness: mild sleepiness that may affect alertness.
  • Headache: transient pain often resolving without intervention.
  • Dry mouth: reduced salivation causing throat discomfort.
  • Fatigue: general feeling of tiredness.
  • Nausea: mild stomach upset.
  • Dizziness: light‑headed sensation, especially when standing quickly.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips or throat requiring immediate medical attention.
  • Severe skin rash or Stevens‑Johnson‑like reactions.
  • Anaphylaxis: rapid, life‑threatening allergic reaction.
  • Cardiac arrhythmia: irregular heart rhythm in susceptible individuals.
  • Hepatic dysfunction: abnormal liver enzymes indicating possible liver injury.

Precautions & Warnings

Before prescribing Mizocler, clinicians should consider several safety aspects.

  • Pregnancy: safety not established; use only if potential benefit outweighs risk.
  • Breastfeeding: unknown excretion in milk; weigh maternal benefit against possible infant exposure.
  • Renal impairment: dose adjustment may be required in severe dysfunction.
  • Elderly patients: monitor for increased sedation or dizziness.
  • Concomitant CNS depressants: avoid or use with caution as additive drowsiness may occur.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Mizocler can interact with other medicines; awareness of the interaction level helps guide monitoring.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: may potentiate antihistaminic effects and cause excessive sedation.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): can increase mizolastine plasma concentrations.
  • Alcohol: additive central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Other antihistamines: may enhance antiallergic effect and increase risk of drowsiness.
  • CNS depressants such as benzodiazepines or opioids: monitor for heightened sedation.
  • Theophylline: may increase risk of tachycardia when combined.

Frequently Asked Questions

Mizocler contains mizolastine, an antihistamine indicated for the relief of symptoms associated with allergic rhinitis and chronic urticaria. It helps reduce nasal congestion, sneezing, itching, and skin hives caused by histamine release.

Mizolastine selectively blocks peripheral H1‑histamine receptors. By preventing histamine from binding to these receptors on mast cells and other tissues, it stops the cascade that leads to vasodilation, increased permeability, and nerve activation, thereby alleviating typical allergic signs.

The appropriate dose of Mizocler is determined by the prescribing healthcare professional based on the patient’s age, condition severity, and renal or hepatic function. Patients should follow the exact regimen provided on the prescription label.

Safety data for mizolastine in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies the possible risk to the fetus or infant, and the decision should be made by a qualified clinician.

To request Mizocler, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mizocler (mizolastine) is a second‑generation H1 antagonist with a lower propensity for sedation compared with first‑generation agents like diphenhydramine. Compared with other second‑generation drugs such as cetirizine or loratadine, mizolastine offers similar efficacy but may have a slightly different side‑effect profile, especially regarding dry mouth.

Mizocler tablets should be stored at ambient temperature, preferably below 25 °C, in their original blister pack. Protect them from excess moisture, heat and direct sunlight to maintain potency throughout the shelf life.

Mizocler is taken orally as a tablet. The tablet should be swallowed whole with a glass of water, preferably at the same time each day, unless otherwise directed by the prescribing physician.

While generally well tolerated, Mizocler can rarely cause severe reactions such as angioedema, anaphylaxis, serious skin eruptions (e.g., Stevens‑Johnson syndrome), cardiac arrhythmias, or significant liver enzyme elevations. Immediate medical attention is required if any of these occur.

Mizocler is contraindicated in individuals with known hypersensitivity to mizolastine or any tablet excipients. Patients with severe hepatic impairment should avoid use, and caution is advised for those with uncontrolled cardiac disease or a history of severe allergic reactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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