Product image of Mizollen (Mizolastine) supplied by GNH India

Mizollen

Active Ingredient:
Mizolastine
Origin:
EU

Mizollen (Mizolastine)

Mizolastine, the active ingredient in Mizollen, is a second‑generation H1 antihistamine presented as an oral tablet for oral use. It alleviates symptoms of allergic rhinitis, urticaria and related allergic conditions in adults and adolescents.

GNH India supplies Mizollen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Desma Pharma

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Indications & Clinical Uses

  • Mizolastine is used to manage allergic conditions mediated by histamine release.
  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and watery discharge.
  • Urticaria: relieves hives and associated itching.
  • Allergic conjunctivitis: helps control eye itching, redness and tearing.

How It Works

  • Mizolastine selectively blocks peripheral H1 receptors, preventing histamine from binding to these sites. By antagonizing the H1 receptor, it inhibits the cascade that leads to vasodilation, increased vascular permeability, and sensory nerve stimulation, thereby reducing the classic signs and symptoms of an allergic response.

Side Effects

Mizollen may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Drowsiness: mild to moderate sedation, especially after the first doses.
  • Headache: transient tension‑type headache.
  • Dry mouth: reduced salivation causing mild discomfort.
  • Fatigue: feeling of reduced energy or tiredness.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Angioedema: rapid swelling of face, lips or throat.
  • Anaphylactic reaction: life‑threatening systemic allergic response.

Precautions & Warnings

  • Before prescribing Mizollen, clinicians should consider several safety aspects.
  • Assess liver function: adjust use if hepatic impairment is present.
  • Avoid driving or operating machinery: drowsiness may impair alertness.
  • Use caution in renal impairment: monitor for accumulation.
  • Not recommended for children under 12 years: safety not established.
  • Avoid concomitant CNS depressants: may increase sedation.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Mizollen can interact with other medicines; awareness of the interaction level helps manage risk.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Other antihistamines: additive sedation and anticholinergic effects.
  • QT‑prolonging drugs: potential for cardiac arrhythmias.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance drowsiness.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increase mizolastine plasma levels.
  • CYP3A4 inducers (e.g., rifampicin): reduce therapeutic effect.

Frequently Asked Questions

Mizollen contains mizolastine, a second‑generation H1 antihistamine indicated for the relief of symptoms associated with allergic rhinitis, chronic urticaria and allergic conjunctivitis. It helps reduce nasal congestion, sneezing, itching, hives and eye irritation caused by histamine release.

Mizolastine works by selectively antagonising peripheral H1 receptors. By blocking histamine from binding to these receptors, it prevents the cascade that leads to vasodilation, increased vascular permeability and sensory nerve activation, thereby mitigating the typical signs of an allergic reaction.

The appropriate dose of Mizollen is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms and clinical response. Dosage recommendations are provided in the product’s prescribing information and should be followed exactly as instructed.

Safety data for mizolastine in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks and consider alternative therapies when appropriate. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician.

To request Mizollen, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with first‑generation antihistamines, mizolastine offers similar efficacy for allergic symptoms but with a lower propensity for sedation and anticholinergic effects. Within the second‑generation class, its potency and duration of action are comparable to agents such as cetirizine and fexofenadine, while maintaining a favorable safety profile.

Mizollen should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments.

Mizollen is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions given by their prescriber to ensure optimal absorption and effectiveness.

The most serious adverse reactions associated with mizolastine include severe skin reactions such as Stevens‑Johnson syndrome, angioedema that can affect breathing, and rare cases of anaphylaxis. Any signs of rash, swelling of the face or throat, or difficulty breathing require immediate medical attention.

Mizollen is contraindicated in individuals with known hypersensitivity to mizolastine or any of the tablet’s excipients. Caution is advised for patients with severe hepatic impairment, and it should not be used in children younger than 12 years unless specifically directed by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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