Product image of Mobius (Memantine Hydrochloride) supplied by GNH India

Mobius

Active Ingredient:
Memantine Hydrochloride
Origin:
EU

Mobius (Memantine Hydrochloride)

Memantine, the active ingredient in Mobius, is an NMDA receptor antagonist presented as an oral tablet for oral use. It is indicated for the treatment of Alzheimer's disease in adult patients, helping to reduce excitotoxic neuronal damage and support cognitive function.

GNH India supplies Mobius as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Customers benefit from consistent product availability and regulatory compliance across EU and other markets.

Manufacturer / TM Owner

Target Pharma Single Member Private Ltd

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Indications & Clinical Uses

  • Memantine acts on the glutamatergic pathway and is approved for specific types of dementia.
  • Alzheimer's disease (moderate to severe): improves cognition, daily functioning, and global clinical status.
  • Alzheimer's disease (mild to moderate): used as adjunct therapy to support cognitive symptoms.
  • Alzheimer's disease with behavioral disturbances: may reduce agitation and improve patient care.

How It Works

  • Memantine is a non‑competitive antagonist of the NMDA (N‑methyl‑D‑aspartate) receptor. By binding to the receptor-associated ion channel at a site distinct from the glutamate binding site, it blocks excessive calcium influx caused by over‑activation of glutamate, thereby reducing excitotoxic neuronal injury while preserving normal synaptic transmission.

Side Effects

Common Side Effects

  • Dizziness
  • Headache
  • Constipation
  • Fatigue
  • Confusion
  • Hypertension

Serious or Rare Side Effects

  • Seizures
  • Cardiac arrhythmias
  • Severe hypersensitivity reactions (e.g., Stevens‑Johnson syndrome)
  • Hepatic injury
  • Suicidal thoughts or behavior
  • Severe skin reactions such as toxic epidermal necrolysis

Precautions & Warnings

Memantine should be used with caution in the following situations:

  • Renal impairment: adjust dose and monitor renal function.
  • History of seizures: use with caution, monitor for seizure activity.
  • Cardiovascular disease: monitor blood pressure and heart rate.
  • Concurrent use with other NMDA antagonists: avoid combination.
  • Pregnancy and lactation: safety not established; weigh risks and benefits.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Memantine may interact with several medicines. Review the following interactions before prescribing:

Major Interactions (Avoid)

  • Amantadine: additive NMDA antagonism may increase toxicity.
  • Ketamine: combined NMDA blockade may cause severe CNS effects.
  • High‑dose anticholinergics: may reduce therapeutic benefit.

Moderate Interactions (Monitor Closely)

  • CNS depressants (e.g., benzodiazepines): may enhance sedation.
  • Diuretics (e.g., furosemide): may increase risk of hypotension.
  • Antihypertensives: monitor blood pressure.

Frequently Asked Questions

Mobius contains memantine hydrochloride and is prescribed for the management of Alzheimer's disease. It helps to improve cognitive function and daily activities in patients with moderate to severe disease by reducing excitotoxic neuronal damage.

Memantine works as a non‑competitive antagonist of the NMDA receptor. By blocking the receptor‑associated ion channel, it limits excessive calcium influx caused by over‑activation of glutamate, thereby protecting neurons from excitotoxic injury while preserving normal neurotransmission.

The dose of Mobius is determined by the prescribing clinician based on the patient’s condition, renal function, and tolerability. No fixed regimen is provided here; the prescriber will set the appropriate dosage and titration schedule.

Safety of memantine during pregnancy and lactation has not been established. The potential benefits must be weighed against possible risks, and use is generally reserved for situations where no suitable alternative exists and the prescriber deems it necessary.

To order Mobius, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Memantine belongs to the NMDA‑receptor antagonist class, whereas the most common alternative for Alzheimer’s disease is the acetylcholinesterase‑inhibitor class (e.g., donepezil). Memantine targets glutamate‑mediated excitotoxicity, while acetylcholinesterase inhibitors enhance cholinergic transmission. Clinical practice often uses them together for complementary effects.

Mobius should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain stability and potency.

Mobius is taken orally, usually as a tablet. It can be swallowed with or without food, according to the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional.

Serious risks include seizures, cardiac arrhythmias, severe hypersensitivity reactions such as Stevens‑Johnson syndrome, hepatic injury, and emergence of suicidal thoughts or behavior. Patients should seek immediate medical attention if any of these events occur.

Mobius is contraindicated in patients with known hypersensitivity to memantine or any of its excipients. Caution is also advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking other NMDA‑receptor antagonists.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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