Product image of Modafen Grip (Phenylephrine Hydrochloride, Ibuprofen) supplied by GNH India

Modafen Grip

Active Ingredient:
Phenylephrine Hydrochloride, Ibuprofen
Origin:
EU

Modafen Grip (Phenylephrine Hydrochloride, Ibuprofen)

Phenylephrine Hydrochloride, the active ingredient in Modafen Grip, is a phenylephrine hydrochloride/ibuprofen combination presented as an oral tablet formulation for oral use. It provides symptomatic relief of nasal congestion, headache, fever and pain associated with cold or flu in adults and children when appropriate.

GNH India supplies Modafen Grip as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory compliance across markets and providing reliable distribution to meet global demand.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Modafen Grip, a phenylephrine and ibuprofen combination, is used to alleviate symptoms of upper respiratory infections and influenza.

  • Nasal congestion: reduces swelling of nasal mucosa, improving airflow.
  • Headache: alleviates pain associated with sinus pressure and flu.
  • Fever and body aches: lowers temperature and eases muscular pain.

How It Works

  • Phenylephrine acts as an alpha‑adrenergic receptor agonist, causing vasoconstriction of nasal blood vessels and reducing mucosal edema. Ibuprofen inhibits cyclooxygenase‑1 and‑2 enzymes, decreasing prostaglandin synthesis, which lowers fever, diminishes inflammation, and provides analgesia. The combined actions address both vascular congestion and inflammatory pain pathways.

Side Effects

Common Side Effects

  • Nausea: mild stomach upset that may occur after oral intake.
  • Dizziness: transient light‑headedness, especially on standing.
  • Insomnia: difficulty falling asleep in some individuals.
  • Dry mouth: reduced salivation leading to throat discomfort.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction with rash, swelling, and breathing difficulty.
  • Gastrointestinal bleeding: ulceration or bleeding in the stomach or intestines.
  • Severe skin reactions: conditions such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before using Modafen Grip, consider the following precautions:

  • Assess cardiovascular status: phenylephrine may raise blood pressure.
  • Avoid in patients with peptic ulcer disease: ibuprofen can exacerbate gastric irritation.
  • Use caution in renal impairment: ibuprofen may affect kidney function.
  • Do not combine with monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Modafen Grip may interact with other medicines as follows:

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other sympathomimetic decongestants: additive vasoconstriction.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: phenylephrine may diminish blood‑pressure control.
  • SSRIs or other serotonergic drugs: may increase bleeding tendency.

Frequently Asked Questions

Modafen Grip is an over‑the‑counter oral tablet that combines phenylephrine and ibuprofen to relieve common cold and flu symptoms such as nasal congestion, headache, fever, and body aches. It is intended for temporary symptomatic relief in adults and, when appropriate, in children.

Phenylephrine is an alpha‑adrenergic receptor agonist. By stimulating these receptors on the blood vessels of the nasal mucosa, it causes vasoconstriction, which reduces swelling and opens the nasal passages, helping to relieve congestion.

The exact dose of Modafen Grip is determined by the prescribing healthcare professional based on the patient’s age, weight, and clinical condition. Patients should follow the prescriber’s instructions and the product labeling.

Safety of phenylephrine and ibuprofen during pregnancy or lactation has not been fully established. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Modafen Grip.

To place an order, submit an enquiry on the Modafen Grip product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Modafen Grip combines a decongestant (phenylephrine) with a non‑steroidal anti‑inflammatory drug (ibuprofen), offering both nasal decongestion and analgesic/antipyretic effects in a single tablet. Many alternatives contain only a single active ingredient, such as a decongestant alone or an acetaminophen‑based analgesic, which may require multiple products to achieve the same breadth of symptom relief.

Store Modafen Grip at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, direct sunlight and excessive heat to maintain potency.

Modafen Grip is taken orally with a full glass of water. It should be swallowed whole and not chewed or crushed unless otherwise directed by a healthcare professional.

Serious risks include severe allergic reactions (anaphylaxis), gastrointestinal bleeding, and rare skin disorders such as Stevens‑Johnson syndrome. Patients experiencing signs of these conditions should seek immediate medical attention.

Modafen Grip should be avoided by individuals with known hypersensitivity to phenylephrine, ibuprofen, or any other component of the tablet, as well as by patients taking monoamine oxidase inhibitors, those with uncontrolled hypertension, active peptic ulcer disease, or severe renal impairment without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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