Product image of Modafen (Pseudoephedrine Hydrochloride, Ibuprofen) supplied by GNH India

Modafen

Active Ingredient:
Pseudoephedrine Hydrochloride, Ibuprofen
Origin:
EU

Modafen (Pseudoephedrine Hydrochloride, Ibuprofen)

Pseudoephedrine Hydrochloride and Ibuprofen, the active ingredients in Modafen, are a sympathomimetic decongestant and a non‑steroidal anti‑inflammatory drug presented as an oral tablet for adult use. It relieves nasal congestion, pain, fever and inflammation associated with colds or flu.

GNH India supplies Modafen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Stada M&d S.R.L.

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Indications & Clinical Uses

Modafen combines a decongestant and an NSAID to address symptoms of upper respiratory infections and related pain.

  • Nasal congestion: reduces swelling of nasal passages, improving airflow.
  • Headache: alleviates tension‑type and sinus‑related headaches.
  • Fever: lowers elevated body temperature through anti‑pyretic action.
  • Pain associated with cold or flu: eases muscular aches, sore throat and sinus pressure.

How It Works

  • Pseudoephedrine acts as an α‑adrenergic agonist, causing vasoconstriction of the nasal mucosa and decreasing edema. Ibuprofen inhibits cyclooxygenase enzymes COX‑1 and COX‑2, reducing prostaglandin synthesis, which provides analgesic, antipyretic and anti‑inflammatory effects.

Side Effects

Modafen may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Insomnia or difficulty sleeping.
  • Nervousness or restlessness.
  • Dry mouth or throat.
  • Nausea or mild gastrointestinal upset.

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching or swelling.
  • Severe skin reactions including Stevens‑Johnson syndrome.
  • Gastrointestinal bleeding or ulceration, especially with prolonged use.

Precautions & Warnings

Before using Modafen, consider the following safety measures.

  • Cardiovascular assessment: avoid in uncontrolled hypertension.
  • Gastrointestinal history: use cautiously in patients with peptic ulcer disease.
  • Drug interactions: review concomitant medications for potential additive effects.
  • Pregnancy and lactation: consult a healthcare professional before use.
  • Age restrictions: not recommended for children without medical advice.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Modafen can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Other sympathomimetic decongestants: may cause excessive vasoconstriction.
  • Concurrent NSAIDs: increase risk of gastrointestinal bleeding.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: pseudoephedrine may reduce their effectiveness.
  • Anticoagulants (e.g., warfarin): ibuprofen can enhance bleeding risk.
  • Lithium: pseudoephedrine may raise serum lithium levels.

Frequently Asked Questions

Modafen is indicated for temporary relief of nasal congestion, headache, fever, and pain associated with common cold or influenza. It combines a decongestant to open nasal passages with an NSAID that reduces pain and fever, providing a convenient single‑tablet option for adults experiencing these symptoms.

Pseudoephedrine hydrochloride stimulates α‑adrenergic receptors in the nasal mucosa, causing blood vessels to constrict. This vasoconstriction reduces swelling and congestion, allowing better airflow through the nasal passages. The effect is localized to the upper respiratory tract and helps alleviate the feeling of a blocked nose.

The specific dose of Modafen is determined by the prescribing healthcare professional based on the patient’s age, weight, medical history and the severity of symptoms. Patients should follow the prescriber’s instructions and the product labeling, and should not exceed the recommended amount without medical guidance.

Safety of Modafen in pregnancy or while breastfeeding has not been definitively established. Women who are pregnant, planning to become pregnant, or nursing should discuss potential risks and benefits with their healthcare provider before using this medication.

To order Modafen, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑ingredient products, Modafen offers both decongestant and anti‑inflammatory actions in one tablet, potentially reducing the need for multiple medications. Alternatives may include separate pseudoephedrine tablets and ibuprofen capsules, but Modafen simplifies dosing and may improve adherence for suitable adult patients.

Modafen should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use it after the expiration date printed on the label.

Modafen is taken orally with a full glass of water. It can be taken with or without food, although taking it with food may reduce stomach irritation. The tablet should be swallowed whole; it should not be chewed, crushed, or dissolved unless directed by a healthcare professional.

Serious risks include severe allergic reactions (e.g., rash, swelling, difficulty breathing), gastrointestinal bleeding or ulceration, and significant increases in blood pressure or heart rate. Patients experiencing any of these symptoms should seek immediate medical attention.

Modafen should be avoided by individuals with known hypersensitivity to pseudoephedrine, ibuprofen or any component of the formulation, those with uncontrolled hypertension, active peptic ulcer disease, severe heart disease, or by children and adolescents for whom safety has not been established without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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