Product image of Modafinil Orifarm (Modafinil) supplied by GNH India

Modafinil Orifarm

Active Ingredient:
Modafinil
Origin:
EU

Modafinil Orifarm (Modafinil)

Modafinil, the active ingredient in Modafinil Orifarm, is a wakefulness‑promoting agent presented as an oral tablet for oral use. It treats excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea, and shift‑work sleep disorder.
GNH India supplies Modafinil Orifarm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

  • Modafinil acts on the central nervous system to improve wakefulness in sleep‑related disorders.
  • Narcolepsy: reduces daytime sleepiness and improves alertness.
  • Obstructive sleep apnea‑related excessive daytime sleepiness: enhances wakefulness despite residual sleep‑disordered breathing.
  • Shift work sleep disorder: decreases sleepiness during scheduled work hours, supporting better performance.

How It Works

  • Modafinil promotes wakefulness primarily by inhibiting dopamine reuptake, leading to increased extracellular dopamine concentrations. It also modulates orexin/hypocretin pathways and influences other neurotransmitter systems such as norepinephrine and histamine, collectively enhancing cortical activation and reducing sleep propensity.

Side Effects

Adverse reactions may occur with Modafinil use.

Common Side Effects

  • Headache
  • Nausea
  • Insomnia
  • Anxiety

Serious or Rare Side Effects

  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Psychiatric disturbances including depression, hallucinations, or mania
  • Cardiovascular events such as hypertension, arrhythmia, or myocardial infarction

Precautions & Warnings

  • Before prescribing Modafinil, clinicians should consider several safety aspects.
  • Assess cardiovascular status: evaluate blood pressure and heart disease before initiating.
  • Monitor psychiatric history: avoid in patients with uncontrolled psychosis.
  • Avoid use in severe hepatic impairment: adjust or contraindicate based on liver function.
  • Inform about potential for dependence: use only as prescribed.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Modafinil can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine): may markedly reduce Modafinil exposure.
  • Co‑administration with other wakefulness‑promoting agents (e.g., armodafinil): risk of excessive stimulation.
  • Monoamine oxidase inhibitors: potential for hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may decrease hormonal efficacy, requiring backup methods.
  • Antidepressants (SSRIs, SNRIs): may increase the incidence of side effects such as anxiety.
  • Antihypertensives: blood pressure changes may necessitate dose adjustment.

Frequently Asked Questions

Modafinil Orifarm is prescribed to manage excessive daytime sleepiness in three recognized sleep disorders: narcolepsy, obstructive sleep apnea‑related sleepiness, and shift‑work sleep disorder. By improving wakefulness, it helps patients maintain alertness during daily activities.

Modafinil primarily blocks the reuptake of dopamine, increasing its concentration in the brain. It also influences orexin/hypocretin pathways and other neurotransmitters such as norepinephrine and histamine, collectively enhancing cortical activation and reducing the drive to sleep.

The specific dose and dosing schedule for Modafinil Orifarm are determined by the prescribing clinician based on the individual’s medical condition, response, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Modafinil in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Modafinil differs from traditional stimulants such as methylphenidate by having a lower risk of cardiovascular stimulation and abuse potential. Compared with armodafinil, its enantiomer, efficacy is similar, though pharmacokinetic profiles may vary slightly.

Modafinil Orifarm should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight to maintain product stability.

Modafinil Orifarm is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, psychiatric events like depression or hallucinations, and cardiovascular complications including hypertension or arrhythmias. Patients should seek immediate medical attention if any of these occur.

Modafinil is contraindicated in individuals with known hypersensitivity to the drug, those with uncontrolled hypertension, severe psychiatric disorders, or significant hepatic impairment. It should also be avoided in patients taking contraindicated medications such as MAO inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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