Product image of Modafinilo Bluefish (Modafinil) supplied by GNH India

Modafinilo Bluefish

Active Ingredient:
Modafinil
Origin:
EU

Modafinilo Bluefish (Modafinil)

Modafinil, the active ingredient in Modafinilo Bluefish, is a eugeroic (wakefulness‑promoting agent) presented as an oral tablet for oral use. It is prescribed to improve wakefulness in patients with narcolepsy, obstructive sleep apnea‑related excessive daytime sleepiness, and shift work sleep disorder.

GNH India supplies Modafinilo Bluefish as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Bluefish Pharmaceuticals Ab

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Indications & Clinical Uses

Modafinil is used to address excessive sleepiness associated with several sleep‑wake disorders.

  • Narcolepsy: reduces daytime sleep attacks and improves alertness.
  • Obstructive sleep apnea‑related excessive daytime sleepiness: mitigates residual sleepiness when used with primary therapy.
  • Shift work sleep disorder: enhances wakefulness during scheduled work periods.

How It Works

  • Modafinil promotes wakefulness primarily by inhibiting dopamine reuptake, increasing extracellular dopamine in key brain regions. It also modulates orexin/hypocretin pathways and influences histamine and norepinephrine signaling, collectively enhancing cortical activation and reducing sleep propensity without acting as a classic stimulant. Additionally, it exerts weak effects on GABAergic transmission, contributing to its overall arousal profile.

Side Effects

Modafinil may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Headache
  • Nausea
  • Insomnia
  • Anxiety
  • Dry mouth
  • Dizziness

Serious or Rare Side Effects

  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Psychiatric events including psychosis or mania
  • Severe allergic reactions (anaphylaxis)
  • Cardiovascular events such as palpitations or hypertension
  • Significant liver enzyme elevations

Precautions & Warnings

Before initiating Modafinilo Bluefish, clinicians should consider several safety factors.

  • Assess cardiovascular status: evaluate blood pressure and heart disease before starting therapy.
  • Review psychiatric history: monitor for emergence of anxiety, depression, or psychosis.
  • Avoid use in uncontrolled hypertension: ensure blood pressure is controlled.
  • Caution in hepatic impairment: adjust dosing or monitor liver function.
  • Pregnancy and lactation: discuss risks with prescriber; use only if benefit outweighs risk.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Modafinil can interact with other medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • CYP3A4 inducers (e.g., rifampin, carbamazepine) markedly reduce modafinil exposure.
  • Hormonal contraceptives: efficacy may be decreased, increasing risk of unintended pregnancy.
  • Monoamine oxidase inhibitors: concurrent use can raise blood pressure.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluoxetine) may increase modafinil plasma levels.
  • Anticoagulants such as warfarin: monitor INR for potential changes.
  • Antihypertensive agents: modafinil may attenuate their blood‑pressure‑lowering effect.
  • Alcohol: combined use can enhance central nervous system effects.

Frequently Asked Questions

Modafinilo Bluefish, containing modafinil, is prescribed to improve wakefulness in adults with narcolepsy, to reduce residual daytime sleepiness in patients with obstructive sleep apnea who are receiving primary therapy, and to help shift‑work employees stay alert during scheduled work periods.

Modafinil enhances alertness by blocking the reuptake of dopamine, which raises dopamine levels in brain regions that regulate arousal. It also activates orexin/hypocretin pathways and influences histamine and norepinephrine signaling, producing a net increase in cortical activity without the strong sympathomimetic effects of traditional stimulants.

The appropriate dose of Modafinilo Bluefish is individualized by the prescribing clinician based on the patient’s diagnosis, response to therapy, and any relevant medical conditions. Dosage adjustments are made according to clinical judgment, and patients should follow the prescriber’s instructions exactly.

Safety data for modafinil in pregnancy and lactation are limited. The drug should be used only if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives and risk assessment with their healthcare provider.

To request Modafinilo Bluefish, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain needs) and the necessary import documentation.

Modafinilo Bluefish (modafinil) differs from traditional stimulants such as methylphenidate by having a lower potential for cardiovascular stimulation and abuse. Compared with armodafinil, its R‑enantiomer, modafinil offers a similar efficacy profile but may require slightly higher doses. Choice of agent depends on individual response, tolerability and prescriber preference.

Store Modafinilo Bluefish tablets at ambient temperature, preferably below 25 °C (77 °F). Keep the product in its original packaging, protect it from moisture and direct light, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Modafinilo Bluefish is taken orally as a tablet. It may be swallowed with or without food, according to the prescriber’s guidance. Patients should avoid crushing or chewing the tablet unless specifically instructed, and should follow the timing recommendations to align wakefulness with their daily schedule.

Serious adverse events, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, psychiatric disturbances like psychosis or mania, significant cardiovascular effects (e.g., hypertension, palpitations), and marked liver enzyme elevations. Any sudden rash, mood change, chest pain, or signs of liver dysfunction should prompt immediate medical evaluation.

Modafinilo Bluefish is contraindicated in individuals with known hypersensitivity to modafinil or any of its excipients. Patients with uncontrolled hypertension, severe cardiovascular disease, or a history of serious psychiatric disorders should avoid the medication unless a specialist determines that benefits outweigh risks. Pregnant or breastfeeding women should only use it under strict medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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