Product image of Modasomil (Modafinil) supplied by GNH India

Modasomil

Active Ingredient:
Modafinil
Origin:
EU

Modasomil (Modafinil)

Modafinil, the active ingredient in Modasomil, is a eugeroic presented as an oral tablet for oral use. It promotes wakefulness and is prescribed for sleep‑related disorders such as narcolepsy, obstructive sleep apnea‑related excessive daytime sleepiness, and shift‑work sleep disorder.

GNH India supplies Modasomil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Pharmaceuticals S.L.

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Indications & Clinical Uses

Modasomil is a central nervous system stimulant indicated for conditions that cause excessive daytime sleepiness.

  • Narcolepsy: reduces daytime sleep attacks and improves alertness.
  • Obstructive sleep apnea‑related excessive daytime sleepiness: mitigates residual sleepiness despite optimal apnea treatment.
  • Shift work sleep disorder: helps maintain wakefulness during scheduled work hours.

How It Works

  • Modafinil promotes wakefulness by selectively inhibiting dopamine reuptake, which increases extracellular dopamine levels. It also activates hypothalamic orexin neurons, enhancing orexin signaling, and stimulates adrenergic pathways, leading to heightened dopaminergic and adrenergic neurotransmission that supports sustained alertness.

Side Effects

Modasomil may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional upset stomach.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dry mouth: reduced salivation.
  • Anxiety: feelings of nervousness or tension.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Rash or Stevens‑Johnson syndrome: severe skin reactions.
  • Psychiatric symptoms: hallucinations or mania.
  • Cardiovascular events: chest pain or arrhythmia.
  • Liver injury: elevated transaminases.
  • Allergic reaction: swelling, difficulty breathing.

Precautions & Warnings

Before prescribing Modasomil, clinicians should consider several safety aspects.

  • Cardiovascular assessment: evaluate history of hypertension or arrhythmias.
  • Psychiatric evaluation: screen for prior psychosis or severe anxiety.
  • Liver function: monitor hepatic enzymes in patients with liver disease.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks.
  • Drug dependence: assess risk of misuse in individuals with substance‑use history.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Modasomil can interact with several medications, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase modafinil plasma levels.
  • CYP2C19 inhibitors (e.g., fluvoxamine): can raise exposure and risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: modafinil may reduce hormonal efficacy; consider alternative contraception.
  • Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome.
  • Antihypertensives: possible reduction in blood pressure control.
  • Caffeine or other stimulants: additive central nervous system stimulation.

Frequently Asked Questions

Modasomil, containing modafinil, is prescribed to manage excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea after adequate respiratory therapy, and shift‑work sleep disorder. It helps patients stay awake and maintain alertness during their daily activities.

Modafinil works by inhibiting the reuptake of dopamine, increasing its concentration in the brain, and by activating hypothalamic orexin neurons. This dual action enhances dopaminergic and adrenergic neurotransmission, which collectively supports sustained alertness and reduces sleep propensity.

The appropriate dose of Modasomil is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and any concomitant medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

The safety of Modasomil in pregnancy and lactation has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Modasomil, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Modasomil (modafinil) differs from traditional stimulants such as methylphenidate by having a lower potential for cardiovascular stimulation and abuse. Its mechanism focuses on dopamine reuptake inhibition and orexin activation, offering wakefulness with a generally favorable side‑effect profile compared with older stimulants.

Modasomil should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability throughout its shelf life.

Modasomil is taken orally, usually with a glass of water. The tablet should be swallowed whole and not crushed or chewed. It is typically taken once daily in the morning, but the exact timing and frequency are determined by the prescriber.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, psychiatric events like hallucinations or mania, and cardiovascular complications such as chest pain or arrhythmias. Patients should seek immediate medical attention if they experience any of these symptoms.

Modasomil is contraindicated in individuals with known hypersensitivity to modafinil or any of its excipients. Caution is advised for patients with uncontrolled hypertension, significant cardiac disease, severe liver impairment, or a history of psychiatric disorders, and it should be avoided in these populations unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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