Modifenac (Diclofenac Sodium)

Diclofenac sodium works by reversibly inhibiting the cyclooxygenase enzymes COX‑1 and COX‑2, which are essential for converting arachidonic acid into prostaglandins. By lowering prostaglandin production, the drug decreases inflammation, pain signalling, and fever, providing symptomatic relief in affected tissues.

The appropriate dose of Modifenac is determined by the prescribing clinician based on the patient’s specific condition, severity of symptoms, age, renal and hepatic function, and any concomitant medications. Dosage regimens are individualized and should follow the prescriber’s instructions and local regulatory guidelines.

Safety of diclofenac during pregnancy and lactation has not been fully established. It is generally advised to avoid NSAIDs, including diclofenac, in the third trimester because of potential fetal cardiovascular effects. Breastfeeding mothers should consult their healthcare provider, as diclofenac can be excreted in breast milk.

To request Modifenac, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will ask for trade or institutional credentials. The sales team then provides pricing, availability, shipping details and any necessary import documentation.

Modifenac (diclofenac) is a potent NSAID with a relatively short half‑life, offering strong analgesic and anti‑inflammatory effects. Compared with ibuprofen, it often provides longer pain relief but may carry a higher risk of gastrointestinal and cardiovascular adverse events. Choice of NSAID should be based on individual risk factors and therapeutic goals.

Modifenac should be stored at ambient temperature below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keep the product out of reach of children and avoid storing it in bathrooms or other humid environments to maintain stability.

Modifenac is intended for oral administration. The tablet or capsule should be swallowed whole with a full glass of water, preferably with food or milk to minimise gastrointestinal irritation. Patients should follow the dosing schedule prescribed by their healthcare professional.

The most serious risks include gastrointestinal bleeding or ulceration, severe skin reactions such as Stevens‑Johnson syndrome, hepatotoxicity, and renal impairment. Cardiovascular events such as myocardial infarction or stroke may also occur, particularly with long‑term use or in patients with existing cardiovascular disease.

Modifenac should be avoided in individuals with known hypersensitivity to diclofenac or any NSAID, those with active peptic ulcer disease, severe heart failure, uncontrolled hypertension, or significant liver or kidney disease. It is also contraindicated in patients who have experienced serious cardiovascular events related to NSAID therapy.