Product image of Modiodal (Modafinil) supplied by GNH India

Modiodal

Active Ingredient:
Modafinil
Origin:
EU

Modiodal (Modafinil)

Modafinil, the active ingredient in Modiodal, is a eugeroic presented as an oral tablet for oral use. It treats excessive daytime sleepiness in narcolepsy, obstructive sleep apnea, and shift work disorder.

GNH India supplies Modiodal as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Modafinil is a central nervous system stimulant indicated for disorders of excessive daytime sleepiness.

  • Narcolepsy: reduces daytime sleepiness and improves wakefulness.
  • Obstructive sleep apnea: helps mitigate residual sleepiness in patients using CPAP therapy.
  • Shift work disorder: promotes alertness during scheduled work hours.

How It Works

  • Modafinil promotes wakefulness primarily by inhibiting the reuptake of dopamine, thereby increasing extracellular dopamine concentrations in key brain regions. It also stimulates orexin/hypocretin neurons and enhances histaminergic and adrenergic signaling, collectively augmenting cortical arousal and reducing sleep propensity.

Side Effects

Modiodal may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Anxiety: feelings of nervousness or tension.
  • Dry mouth: reduced salivation.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Severe rash or Stevens‑Johnson syndrome: requires immediate medical attention.
  • Psychiatric symptoms: hallucinations, mania, or depression.
  • Cardiovascular events: hypertension, palpitations, or arrhythmia.
  • Allergic reactions: swelling, bronchospasm, or anaphylaxis.
  • Liver injury: elevated transaminases or hepatitis.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate individual risk factors and monitor patients regularly.

  • Cardiovascular assessment: screen for hypertension or arrhythmias.
  • Psychiatric history: monitor for anxiety, depression, or psychosis.
  • Hypersensitivity: avoid in patients with known allergy to modafinil.
  • Hepatic impairment: consider dose adjustment in severe liver disease.
  • Pregnancy and breastfeeding: safety not established; weigh benefits against potential risks.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Modiodal can interact with several drug classes, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase modafinil plasma levels.
  • CYP3A4 inducers (e.g., rifampin, carbamazepine): reduce therapeutic effect.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: may reduce hormonal efficacy.
  • Antidepressants (SSRIs, SNRIs): potential increase in side‑effect burden.

Frequently Asked Questions

Modiodal contains modafinil, which is prescribed to improve wakefulness in patients with excessive daytime sleepiness caused by narcolepsy, obstructive sleep apnea (when residual sleepiness persists despite therapy), and shift work disorder. It helps individuals maintain alertness during scheduled waking periods.

Modafinil enhances alertness by blocking the reuptake of dopamine, leading to higher dopamine levels in the brain. It also activates orexin neurons and stimulates histamine and norepinephrine pathways, collectively increasing cortical arousal and reducing the drive to sleep.

The appropriate dose of Modiodal is determined by a qualified prescriber based on the patient’s medical condition, response to therapy, and individual tolerability. Dosage may be adjusted over time, and patients should follow the prescribing clinician’s instructions.

Safety data for modafinil in pregnancy and lactation are limited. The drug is classified as having an unknown risk, so clinicians must weigh potential benefits against possible risks to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their healthcare provider.

To request Modiodal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Modiodal (modafinil) is a first‑generation eugeroic, whereas armodafinil is its R‑enantiomer with a slightly longer half‑life. Both share similar efficacy, but individual response and tolerability can differ. Traditional stimulants such as methylphenidate act primarily on norepinephrine and dopamine reuptake and may have a higher risk of cardiovascular side effects.

Modiodal tablets should be stored at ambient temperature below 25 °C, in the original container, and protected from moisture and direct sunlight. Keep the product out of reach of children and do not use after the expiration date printed on the packaging.

Modiodal is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance regarding timing relative to meals to optimize tolerability and effectiveness.

Serious adverse events, although rare, include severe skin reactions such as Stevens‑Johnson syndrome, psychiatric disturbances (e.g., hallucinations, mania, depression), and cardiovascular complications like hypertension or arrhythmias. Patients should seek immediate medical attention if they experience rash, mood changes, chest pain, or palpitations.

Modiodal is contraindicated in individuals with known hypersensitivity to modafinil or any of its excipients. Caution is advised for patients with uncontrolled hypertension, significant cardiac disease, severe hepatic impairment, or a history of psychiatric disorders. Pregnant or breastfeeding women should only use it if the potential benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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