Product image of Modiodal (Modafinil) supplied by GNH India

Modiodal

Active Ingredient:
Modafinil
Origin:
EU

Modiodal (Modafinil)

Modafinil, the active ingredient in Modiodal, is a eugeroic presented as an oral formulation for oral use. It promotes wakefulness in patients with narcolepsy, obstructive sleep apnea, and shift work sleep disorder.

GNH India supplies Modiodal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

  • Modiodal is a central nervous system stimulant indicated for sleep‑related disorders.
  • Narcolepsy: reduces excessive daytime sleepiness and improves alertness.
  • Obstructive sleep apnea: helps maintain wakefulness in patients receiving standard therapy.
  • Shift work sleep disorder: alleviates sleepiness during scheduled work hours.

How It Works

  • Modafinil enhances wakefulness by inhibiting dopamine reuptake, which increases extracellular dopamine concentrations in the brain. It also stimulates hypothalamic orexin neurons, contributing to heightened arousal. These actions collectively promote alertness without the typical sympathomimetic effects of traditional stimulants.

Side Effects

Modiodal may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Headache
  • Nausea
  • Insomnia
  • Anxiety
  • Dry mouth
  • Diarrhea

Serious or Rare Side Effects

  • Severe rash or Stevens‑Johnson syndrome
  • Psychiatric symptoms such as hallucinations or mania
  • Cardiovascular events including hypertension or arrhythmia
  • Hepatic dysfunction
  • Allergic reactions with swelling or difficulty breathing

Precautions & Warnings

  • Before prescribing Modiodal, consider the following safety measures.
  • Assess cardiovascular status: evaluate blood pressure and heart rate prior to initiation.
  • Review psychiatric history: monitor for emergence of anxiety, depression, or psychosis.
  • Consider hepatic function: adjust use in patients with liver impairment.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce rebound sleepiness.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Modiodal can interact with several medication classes; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase plasma concentrations.
  • CYP3A4 inducers (e.g., rifampicin): may reduce therapeutic effect.
  • Oral contraceptives: may decrease contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antidepressants (especially SSRIs): monitor for heightened side effects.
  • Antihypertensives: observe blood pressure for potential changes.
  • Anticoagulants: watch for altered bleeding risk.

Frequently Asked Questions

Modiodal contains modafinil, which is prescribed to improve wakefulness in adults diagnosed with narcolepsy, obstructive sleep apnea, or shift work sleep disorder. It helps reduce excessive daytime sleepiness associated with these conditions, allowing patients to maintain better alertness during daily activities.

Modafinil primarily inhibits the reuptake of dopamine, increasing its concentration in the brain. It also activates hypothalamic orexin neurons, which play a key role in regulating arousal. Together, these actions enhance alertness without the strong sympathomimetic effects seen with traditional stimulants.

The appropriate dose of Modiodal is determined by a qualified prescriber based on the individual’s medical condition, response to therapy, and overall health status. Healthcare professionals will tailor the regimen to achieve optimal wakefulness while minimizing potential adverse effects.

Safety data for modafinil in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Clinicians should weigh potential benefits against possible risks and consider alternative therapies when treating pregnant or nursing individuals.

To request Modiodal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifying trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Modiodal (modafinil) differs from traditional stimulants such as methylphenidate by having a lower propensity for cardiovascular stimulation and a longer half‑life, which provides sustained wakefulness with once‑daily dosing. Its mechanism focuses on dopamine reuptake inhibition and orexin activation rather than direct adrenergic stimulation.

Modiodal should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture and direct sunlight to maintain stability throughout its shelf life.

Modiodal is taken orally, typically with a glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing relative to meals to ensure consistent absorption.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, psychiatric events like hallucinations or mania, and cardiovascular complications such as hypertension or arrhythmia. Patients should seek immediate medical attention if they experience rash, mood changes, chest pain, or difficulty breathing.

Modiodal is contraindicated in individuals with known hypersensitivity to modafinil or any of its excipients. Caution is advised for patients with uncontrolled hypertension, significant cardiac disease, or a history of severe psychiatric disorders. Clinicians should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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