Product image of Modiodal (Modafinil) supplied by GNH India

Modiodal

Active Ingredient:
Modafinil
Origin:
EU

Modiodal (Modafinil)

Modafinil, the active ingredient in Modiodal, is a eugeroic (wakefulness‑promoting agent) presented as an oral dosage form for oral use. It is indicated for the treatment of narcolepsy, excessive daytime sleepiness associated with obstructive sleep apnea, and shift work disorder in adults.

GNH India supplies Modiodal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Modiodal is a wakefulness‑promoting agent used in several sleep‑related disorders.

  • Narcolepsy: reduces daytime sleep attacks and improves alertness.
  • Obstructive sleep apnea‑related excessive daytime sleepiness: mitigates residual sleepiness when standard therapy is insufficient.
  • Shift work disorder: helps maintain alertness during scheduled work hours that fall outside the normal circadian rhythm.

How It Works

  • Modafinil inhibits the reuptake of dopamine, leading to increased extracellular dopamine concentrations in key brain regions. It also modulates orexin, histamine, norepinephrine, and serotonin pathways, collectively enhancing cortical activation and promoting sustained wakefulness without the typical stimulant‑like surge in sympathetic activity.

Side Effects

Modiodal may cause a range of adverse reactions, most of which are mild to moderate.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Anxiety or nervousness: transient feelings of tension.
  • Dizziness: light‑headed sensation.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe rash or Stevens‑Johnson syndrome: requires immediate medical attention.
  • Psychiatric symptoms: emergence of hallucinations, mania, or depression.
  • Cardiac arrhythmia: irregular heart rhythm in susceptible individuals.
  • Anaphylactic reaction: rapid onset of swelling, breathing difficulty, or hypotension.

Precautions & Warnings

Before initiating Modiodal, clinicians should consider several safety factors.

  • Cardiovascular assessment: evaluate blood pressure and heart rhythm.
  • Psychiatric history: monitor for pre‑existing mood disorders.
  • Hepatic function: adjust use in moderate to severe liver impairment.
  • Concomitant stimulants: avoid combining with other central nervous system stimulants.
  • Pregnancy and lactation: discuss potential risks with the prescriber.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Modiodal can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma levels.
  • Serotonergic antidepressants: potential for serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: reduced hormonal efficacy, consider alternative contraception.
  • Antihypertensive agents: possible attenuation of blood‑pressure‑lowering effect.
  • Caffeine‑containing products: heightened stimulant effect.
  • Alcohol: additive central nervous system depression.

Frequently Asked Questions

Modiodal contains the active ingredient modafinil and is prescribed to improve wakefulness in adults with narcolepsy, excessive daytime sleepiness linked to obstructive sleep apnea, and shift work disorder. It helps reduce unintended sleep episodes and supports sustained alertness during scheduled waking periods.

Modafinil primarily blocks the reuptake of dopamine, raising its concentration in the brain. It also influences orexin, histamine, norepinephrine, and serotonin systems, which together enhance cortical activation and reduce the propensity for sleep without causing the rapid heart‑rate spikes typical of classic stimulants.

The specific dose of Modiodal is determined by the prescribing clinician based on the patient’s condition, response, and overall health profile. Healthcare professionals follow established guidelines and adjust the regimen as needed, ensuring individualized and safe therapy.

Safety data for modafinil in pregnancy and lactation are limited. The prescriber should weigh potential benefits against unknown risks and discuss alternative options when possible. Women who are pregnant, planning pregnancy, or breastfeeding should consult their healthcare provider before using Modiodal.

To request Modiodal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Modiodal (modafinil) differs from traditional stimulants such as methylphenidate by offering a lower risk of cardiovascular stimulation and a longer duration of action. Compared with armodafinil, its racemic counterpart, Modiodal provides similar efficacy but may have a slightly different side‑effect profile, allowing clinicians to choose based on patient tolerance.

Modiodal should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, heat, and direct sunlight. Do not store in bathrooms or near kitchen appliances that generate excess humidity.

Modiodal is taken orally, usually with a glass of water. The tablet is swallowed whole and not intended to be chewed, crushed, or split unless specifically instructed by a healthcare professional. It is generally taken once daily in the morning to align with the patient’s waking schedule.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, psychiatric events like hallucinations or mania, and rare cardiac arrhythmias. Patients should seek immediate medical attention if they notice rash, mood changes, chest pain, or irregular heartbeat while using Modiodal.

Modiodal is contraindicated in individuals with known hypersensitivity to modafinil or any of its excipients. It should also be avoided in patients taking monoamine oxidase inhibitors within 14 days, those with uncontrolled hypertension, and persons with a history of severe psychiatric disorders unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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