Product image of Modiodal (Modafinil) supplied by GNH India

Modiodal

Active Ingredient:
Modafinil
Origin:
EU

Modiodal (Modafinil)

Modafinil, the active ingredient in Modiodal, is a eugeroic presented as a tablet for oral use. It is prescribed to improve wakefulness in adults with narcolepsy, shift work sleep disorder, and, off‑label, in obstructive sleep apnea patients who experience residual daytime sleepiness.

GNH India supplies Modiodal as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva Pharma B.V.

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Indications & Clinical Uses

Modiodal is a central nervous system stimulant used to address disorders of excessive daytime sleepiness.

  • Narcolepsy: reduces daytime sleepiness and improves alertness.
  • Shift work sleep disorder: helps maintain wakefulness during scheduled work hours.
  • Obstructive sleep apnea (off‑label): may improve residual sleepiness in patients already receiving standard therapy.

How It Works

  • Modafinil inhibits the reuptake of dopamine, increasing extracellular dopamine levels, and activates orexin and histamine pathways in the hypothalamus. These actions collectively promote cortical arousal and sustain wakefulness without markedly affecting other neurotransmitter systems.

Side Effects

Modiodal may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Nausea: occasional gastrointestinal upset.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dry mouth: reduced salivation.
  • Anxiety: feelings of nervousness or tension.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reactions requiring immediate medical attention.
  • Cardiovascular events: chest pain or arrhythmias in susceptible individuals.
  • Psychiatric disturbances: hallucinations or severe mood changes.

Precautions & Warnings

When prescribing Modiodal, clinicians should consider several safety aspects.

  • Cardiovascular assessment: evaluate history of hypertension or heart disease.
  • Psychiatric evaluation: screen for pre‑existing psychosis or severe anxiety.
  • Liver function: monitor in patients with hepatic impairment.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks.
  • Drug dependence: assess risk of misuse in patients with substance‑use history.
  • Store at ambient temperature: keep below 25°C in the original packaging, protected from moisture and direct sunlight.

Avoid Interactions

Modiodal can interact with several medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase modafinil plasma levels.
  • CYP2C19 inhibitors (e.g., fluvoxamine): can raise exposure and risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: modafinil may reduce hormonal efficacy, requiring alternative contraception.
  • Antidepressants (SSRIs, SNRIs): may increase risk of serotonin syndrome.
  • Anticoagulants (warfarin): potential alteration of INR, requiring closer monitoring.

Frequently Asked Questions

Modiodal, containing modafinil, is indicated for the management of excessive daytime sleepiness associated with narcolepsy, shift work sleep disorder, and, off‑label, obstructive sleep apnea when residual sleepiness persists despite standard therapy.

Modafinil primarily blocks dopamine reuptake, raising extracellular dopamine levels, and also stimulates orexin and histamine pathways in the hypothalamus. These combined actions enhance cortical arousal and sustain alertness without causing the pronounced stimulation seen with traditional stimulants.

The appropriate dose of Modiodal is determined by the prescribing clinician based on the individual’s medical condition, response, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

The safety of Modiodal in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To request Modiodal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Modiodal (modafinil) differs from traditional stimulants such as methylphenidate by having a lower potential for cardiovascular stimulation and abuse. Its mechanism focuses on dopamine reuptake inhibition and orexin activation, offering wakefulness with a generally smoother side‑effect profile.

Store Modiodal at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture, heat, and direct sunlight to maintain potency throughout the shelf life.

Modiodal is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their prescriber regarding timing and any dietary considerations.

Serious adverse reactions, though rare, include severe skin reactions such as Stevens‑Johnson syndrome, cardiovascular events like chest pain or arrhythmias, and psychiatric disturbances including hallucinations or severe mood changes. Immediate medical attention is required if any of these occur.

Modiodal is contraindicated in individuals with known hypersensitivity to modafinil or any of its excipients. Caution is advised for patients with uncontrolled hypertension, significant cardiac disease, severe hepatic impairment, or a history of psychiatric disorders, and it should be avoided in pregnancy unless clearly needed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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