Moditen (Fluphenazine Hydrochloride)

Fluphenazine works by blocking dopamine D2 receptors in the brain, which lowers dopaminergic activity that is thought to contribute to psychotic symptoms. It also antagonises serotonin, histamine and muscarinic receptors, influencing mood, sedation and other pharmacologic effects.

The appropriate dose of Moditen is determined by the prescribing clinician based on the individual’s clinical condition, response to therapy and tolerability. Dosage adjustments are made during treatment to achieve optimal symptom control while minimizing side effects.

Safety data for fluphenazine in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare professional.

To order Moditen, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Moditen (fluphenazine) is a typical, first‑generation antipsychotic that primarily blocks dopamine D2 receptors, often producing more extrapyramidal side effects than atypical agents. Atypical antipsychotics such as risperidone or olanzapine have broader receptor profiles and may have lower risk of motor side effects but differ in metabolic profiles.

Moditen should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and excessive heat to maintain stability and potency throughout its shelf life.

Moditen is supplied as an oral tablet intended for swallowing with water. It is taken by mouth, usually once or multiple times daily as directed by the prescriber, and should be taken with or without food according to individual tolerability.

The most serious risks include neuroleptic malignant syndrome, a potentially fatal reaction characterized by fever and muscle rigidity; tardive dyskinesia, which may become permanent; severe hypotension; and cardiac arrhythmias such as QT prolongation. Immediate medical attention is required if any of these occur.

Moditen is contraindicated in individuals with known hypersensitivity to fluphenazine or any phenothiazine component, patients with severe central nervous system depression, and those taking medications that may cause dangerous additive effects, such as certain QT‑prolonging drugs. It should also be used with caution in the elderly with dementia‑related psychosis.