Product image of Modopar 62,5 (Benserazide Hydrochloride, Levodopa) supplied by GNH India

Modopar 62,5

Active Ingredient:
Benserazide Hydrochloride, Levodopa
Origin:
EU

Modopar 62,5 (Benserazide Hydrochloride, Levodopa)

Levodopa/Benserazide, the active ingredient in Modopar 62,5, is a dopamine precursor/dopa decarboxylase inhibitor presented as a 62.5 mg oral tablet for oral use. It treats Parkinson's disease and related Parkinsonian syndromes in adult patients.

GNH India supplies Modopar 62,5 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Roche

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Indications & Clinical Uses

  • Modopar 62,5, a combination of levodopa and benserazide, is used in the management of Parkinsonian disorders by restoring central dopamine levels.
  • Parkinson's disease: improves motor symptoms such as tremor, rigidity and bradykinesia.
  • Parkinsonian syndrome: alleviates motor deficits associated with the syndrome.
  • Secondary Parkinsonism: provides symptomatic relief when caused by drug‑induced or vascular factors.

How It Works

  • Levodopa crosses the blood‑brain barrier and is decarboxylated to dopamine within the central nervous system. Benserazide, a peripheral dopa decarboxylase inhibitor, prevents the conversion of levodopa to dopamine outside the brain, thereby increasing the amount of levodopa that reaches the CNS and enhancing dopaminergic neurotransmission.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Orthostatic hypotension: dizziness upon standing.
  • Headache: transient cranial discomfort.
  • Insomnia: difficulty initiating or maintaining sleep.
  • Dyskinesia: involuntary movements, especially at higher doses.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure drop requiring medical attention.
  • Psychosis or hallucinations: visual or auditory disturbances.
  • Cardiac arrhythmias: irregular heart rhythms in susceptible individuals.
  • Neuroleptic malignant syndrome: rare but life‑threatening reaction.
  • Severe dyskinesia: disabling involuntary movements.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety aspects.

  • Monitor blood pressure: check for orthostatic changes, especially after dose adjustments.
  • Assess for dyskinesia: observe for involuntary movements during follow‑up.
  • Review psychiatric status: watch for hallucinations or mood changes.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent withdrawal.
  • Store at ambient temperature: keep in the original pack, protect from moisture and light.

Avoid Interactions

Levodopa/benserazide may interact with several medicines; careful review is essential.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: risk of hypertensive crisis.
  • Antipsychotics (dopamine antagonists): may diminish therapeutic effect.
  • High‑dose pyridoxine (vitamin B6): accelerates peripheral levodopa metabolism.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: additive blood‑pressure lowering.
  • SSRIs or SNRIs: potential for serotonin syndrome.
  • Iron or calcium supplements: may reduce levodopa absorption if taken simultaneously.

Frequently Asked Questions

Modopar 62,5 is prescribed to manage the motor symptoms of Parkinson's disease and Parkinsonian syndrome. It works by increasing dopamine levels in the brain, helping to reduce tremor, stiffness, and slowness of movement in adult patients.

Levodopa is a dopamine precursor that crosses the blood‑brain barrier and is converted to dopamine in the central nervous system. Benserazide inhibits the peripheral enzyme dopa decarboxylase, preventing premature conversion of levodopa outside the brain and thereby enhancing its central availability.

The specific dose of Modopar 62,5 is determined by the prescribing clinician based on the individual’s disease severity, response to therapy, and tolerability. Patients should follow the dosage instructions provided by their healthcare professional.

The safety of Modopar 62,5 in pregnancy or while breastfeeding has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Modopar 62,5 combines levodopa with benserazide, offering a direct dopamine replacement strategy. Compared with dopamine agonists, it generally provides more robust symptom control but may have a higher risk of motor complications such as dyskinesia. Choice of therapy depends on individual patient factors and physician judgment.

Store Modopar 62,5 tablets at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Modopar 62,5 is taken orally, usually with a glass of water. It may be taken with or without food, but consistent timing relative to meals can help minimize gastrointestinal side effects. Patients should follow the dosing schedule prescribed by their clinician.

Serious risks include severe hypotension, neuroleptic malignant syndrome, significant dyskinesia, and psychiatric disturbances such as hallucinations or psychosis. Patients should be monitored closely for these events, and any sudden or severe symptoms should prompt immediate medical evaluation.

Modopar 62,5 is contraindicated in patients with known hypersensitivity to levodopa, benserazide, or any excipients, and in those taking non‑selective MAO inhibitors. Caution is also advised for individuals with a history of severe cardiovascular disease, uncontrolled hypertension, or psychiatric disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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