Product image of Modrasil (Sildenafil Citrate) supplied by GNH India

Modrasil

Active Ingredient:
Sildenafil Citrate
Origin:
EU

Modrasil (Sildenafil Citrate)

Sildenafil, the active ingredient in Modrasil, is a phosphodiesterase type 5 inhibitor presented as an oral tablet for oral use. It treats erectile dysfunction and pulmonary arterial hypertension in adult patients.

GNH India supplies Modrasil as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Farmak International Sp. Z O.O.

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Indications & Clinical Uses

Modrasil is a phosphodiesterase type 5 inhibitor used in conditions affecting vascular smooth muscle tone.

  • Erectile dysfunction: improves the ability to achieve and maintain an erection.
  • Pulmonary arterial hypertension: enhances exercise capacity and reduces pulmonary arterial pressure.
  • Erectile dysfunction in men with diabetes: improves erectile response in diabetic patients.

How It Works

  • Sildenafil selectively inhibits the enzyme phosphodiesterase type 5, preventing the breakdown of cyclic guanosine monophosphate (cGMP). Elevated cGMP levels lead to relaxation of smooth muscle in the corpus cavernosum and pulmonary vasculature, facilitating increased blood flow and improved erectile function or reduced pulmonary arterial pressure.

Side Effects

Common Side Effects

  • Headache
  • Flushing
  • Dyspepsia
  • Nasal congestion

Serious or Rare Side Effects

  • Priapism (prolonged erection)
  • Severe hypotension
  • Sudden hearing loss

Precautions & Warnings

Before prescribing Modrasil, consider the following precautions:

  • Cardiovascular assessment: evaluate for recent myocardial infarction or unstable angina.
  • Nitrate use: avoid co‑administration with any nitrate medication.
  • Hepatic/renal function: adjust use in severe impairment.
  • Visual disorders: caution in patients with retinitis pigmentosa.
  • Sexual activity timing: advise patients to wait for the drug’s effect to subside before repeated dosing.
  • Store at room temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Modrasil may interact with several medicines.

Major Interactions (Avoid)

  • Nitrates (e.g., nitroglycerin)
  • Guanylate cyclase stimulators (e.g., riociguat)
  • Protease inhibitors (e.g., ritonavir)

Moderate Interactions (Monitor Closely):\n- Strong CYP3A4 inhibitors (e.g., erythromycin)

  • Strong CYP3A4 inducers (e.g., rifampicin)

Frequently Asked Questions

Modrasil contains sildenafil citrate and is used to treat erectile dysfunction and pulmonary arterial hypertension in adult patients. It works by improving blood flow to the penis or the pulmonary arteries, helping achieve the intended therapeutic outcomes.

Sildenafil blocks phosphodiesterase type 5, an enzyme that degrades cGMP. By preserving cGMP, it promotes smooth‑muscle relaxation in the corpus cavernosum and pulmonary vessels, increasing blood flow and facilitating erection or lowering pulmonary arterial pressure.

The appropriate dose of Modrasil is determined by a qualified prescriber based on the patient’s condition, response, and any concomitant medications. Patients should follow the prescribing information provided by their healthcare professional.

The safety of sildenafil in pregnancy or while breastfeeding has not been established. It is generally not recommended for use in these populations unless a prescriber determines that the potential benefits outweigh the risks.

To order Modrasil, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Modrasil (sildenafil) belongs to the phosphodiesterase type 5 inhibitor class, similar to drugs such as tadalafil and vardenafil. While all share a common mechanism, differences exist in onset of action, duration of effect and dosing flexibility, which clinicians consider when selecting therapy.

Modrasil should be stored at room temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, heat and direct sunlight to maintain product stability.

Modrasil is taken orally, usually with water, about 30 minutes to 1 hour before sexual activity or as directed for pulmonary hypertension. The tablet should be swallowed whole and not crushed or chewed.

Serious risks include priapism (a prolonged erection lasting more than four hours), severe hypotension especially when combined with nitrates, sudden hearing loss, and rare visual disturbances. Patients experiencing any of these should seek immediate medical attention.

Modrasil is contraindicated in patients taking nitrates, those with severe uncontrolled hypertension, recent myocardial infarction, severe hepatic impairment, or known hypersensitivity to sildenafil or any tablet excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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