Modrasone (Alclometasone Dipropionate)

Modrasone, a topical corticosteroid, is applied to inflammatory skin disorders to reduce redness, swelling and itching.

• Eczema (atopic dermatitis): diminishes inflammation and pruritus, promoting skin healing.
• Contact dermatitis: alleviates allergic skin reactions and reduces lesion size.
• Seborrheic dermatitis: controls scaling and erythema on scalp and face.
• Psoriasis (mild to moderate): softens plaques and limits flare‑ups.
• Other inflammatory skin disorders: provides anti‑inflammatory relief in various dermatologic conditions.

• Alclometasone Dipropionate penetrates the epidermis and binds to intracellular glucocorticoid receptors. The drug‑receptor complex translocates to the nucleus, where it modulates gene transcription, suppressing pro‑inflammatory cytokine production, decreasing leukocyte migration, and inhibiting immune cell activation, resulting in reduced skin inflammation and edema.

Adverse reactions may occur with topical use of Alclometasone Dipropionate. Patients should be aware of both frequent and rare events.

Common Side Effects

• Burning or stinging sensation at the application site
• Pruritus or mild itching
• Dryness or flaking of the skin
• Erythema or mild redness
• Folliculitis or small pustules
• Skin irritation or tenderness

Serious or Rare Side Effects

• Skin atrophy or thinning
• Hypopigmentation or depigmentation
• Allergic contact dermatitis
• Secondary bacterial, fungal or viral infection
• Systemic absorption leading to adrenal suppression
• Severe hypersensitivity reactions such as angioedema

Before using Modrasone, consider the following safety measures.

• Assess severity: limit use to mild‑moderate conditions and short‑term therapy.
• Indicated areas only: apply to intact skin, avoiding eyes, mucous membranes and broken skin.
• Occlusion caution: do not cover treated area with airtight dressings unless directed.
• Infection risk: avoid use on infected or ulcerated skin without medical supervision.
• Systemic monitoring: watch for signs of systemic corticosteroid effects during prolonged use.
• Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Topical corticosteroids can interact with other agents applied to the skin or systemic drugs.

Major Interactions (Avoid)

• Systemic corticosteroids: may increase risk of systemic side effects.
• Potent CYP3A4 inducers (e.g., rifampicin): could reduce local efficacy.
• Antifungal agents (e.g., ketoconazole): may alter skin barrier and affect absorption.

Moderate Interactions (Monitor Closely)

• Topical antibiotics or antiseptics: monitor for irritation or reduced steroid potency.
• Other topical immunomodulators (e.g., tacrolimus): assess combined immunosuppressive effect.
• Skin care products containing alcohol or fragrances: may increase irritation risk.