Product image of Moduxin Mr (Trimetazidine Dihydrochloride) supplied by GNH India

Moduxin Mr

Active Ingredient:
Trimetazidine Dihydrochloride
Origin:
EU

Moduxin Mr (Trimetazidine Dihydrochloride)

Trimetazidine, the active ingredient in Moduxin Mr, is a metabolic modulator (anti‑ischemic agent) presented as an oral dosage form for systemic use. It is prescribed to improve myocardial efficiency in patients with chronic stable angina, coronary artery disease, and peripheral arterial disease.

GNH India supplies Moduxin Mr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Gedeon Richter România S.A.

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Indications & Clinical Uses

Moduxin Mr is used as an anti‑ischemic agent to manage conditions where myocardial oxygen supply is limited.

  • Chronic stable angina pectoris: reduces frequency of angina attacks and improves exercise tolerance.
  • Coronary artery disease: enhances cardiac metabolic efficiency during ischemic episodes.
  • Peripheral arterial disease: alleviates intermittent claudication by improving muscle oxygen utilization.

How It Works

  • Trimetazidine inhibits mitochondrial long‑chain 3‑ketoacyl‑CoA thiolase, which shifts myocardial energy metabolism from fatty‑acid oxidation toward glucose oxidation. This metabolic switch requires less oxygen per unit of ATP produced, thereby enhancing cardiac efficiency under ischemic conditions and reducing anginal symptoms.

Side Effects

Adverse reactions may occur with Trimetazidine therapy.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Dizziness: sensation of light‑headedness, especially on standing.
  • Gastrointestinal discomfort: abdominal pain or dyspepsia.
  • Skin rash: mild erythematous eruptions.

Serious or Rare Side Effects

  • Parkinsonian symptoms: tremor, rigidity, or bradykinesia.
  • Severe allergic reaction: anaphylaxis, angioedema, or bronchospasm.
  • Hepatic dysfunction: elevated liver enzymes or jaundice.
  • Hematologic abnormalities: leukopenia or thrombocytopenia.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Renal impairment: adjust use in patients with severe kidney dysfunction.
  • Hepatic disease: monitor liver function tests regularly.
  • Neurological disorders: avoid in patients with Parkinson's disease or movement disorders.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Concomitant anti‑arrhythmic drugs: monitor for additive cardiac effects.
  • Store at ambient temperature: keep below 25 °C, in the original container, protected from moisture and direct sunlight.

Avoid Interactions

Trimetazidine may interact with other medicines; awareness of interaction severity is essential.

Major Interactions (Avoid)

  • Antiparkinsonian agents: may exacerbate movement disorders.
  • Strong CYP2D6 inhibitors: could increase plasma levels of Trimetazidine.

Moderate Interactions (Monitor Closely)

  • Antihypertensive drugs: additive blood pressure lowering effect.
  • Diuretics: monitor electrolyte balance and renal function.
  • Other anti‑ischemic agents: assess for overlapping therapeutic effects and side‑effect profiles.

Frequently Asked Questions

Moduxin Mr contains Trimetazidine, a metabolic modulator indicated for chronic stable angina, coronary artery disease, and peripheral arterial disease. It helps improve heart muscle efficiency during episodes of reduced oxygen supply.

Trimetazidine inhibits mitochondrial long‑chain 3‑ketoacyl‑CoA thiolase, shifting heart muscle energy production from fatty‑acid oxidation to glucose oxidation. This change requires less oxygen for the same amount of ATP, enhancing cardiac performance under ischemic conditions.

The specific dose of Moduxin Mr is determined by the prescribing clinician based on the patient’s condition, severity, and response to therapy. Dosage adjustments are made according to individual therapeutic needs.

Safety data for Trimetazidine in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Unlike nitrates or calcium‑channel blockers that primarily dilate vessels, Trimetazidine acts at the cellular level to improve myocardial metabolism. This distinct mechanism can be complementary to other anti‑anginal agents, offering an alternative for patients who need metabolic support.

Store Moduxin Mr at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability.

Moduxin Mr is taken orally, usually with or without food, as directed by the prescribing physician. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed.

Serious adverse reactions, though rare, include Parkinsonian symptoms such as tremor or rigidity, severe allergic responses like anaphylaxis, and significant liver enzyme elevations. Patients should seek immediate medical attention if these occur.

Moduxin Mr is contraindicated in patients with known hypersensitivity to Trimetazidine or any excipients, and it should be avoided in individuals with Parkinson’s disease or other movement disorders due to the risk of symptom aggravation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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