Mofur (Mometasone Furoate)

• Mometasone Furoate is used topically to manage inflammatory skin disorders.
• Eczema: alleviates redness, swelling, and itching, helping restore skin barrier function in affected areas.
• Psoriasis: reduces plaque formation and scaling, providing symptomatic relief in chronic plaque psoriasis.
• Atopic dermatitis: diminishes flare‑ups by suppressing immune‑mediated inflammation and pruritus.
• Contact dermatitis: mitigates acute inflammatory response caused by irritants or allergens, decreasing erythema and discomfort.

• Mometasone Furoate binds to intracellular glucocorticoid receptors in keratinocytes and immune cells. The receptor complex translocates to the nucleus, where it interacts with glucocorticoid response elements, modulating transcription of anti‑inflammatory proteins and repressing pro‑inflammatory cytokines such as IL‑1, IL‑6, and TNF‑α. This results in reduced cellular infiltration, edema, and immune activation in the skin.

Topical application of Mometasone Furoate may be associated with local and, rarely, systemic adverse reactions.

Common Side Effects

• Skin irritation or burning sensation
• Pruritus or itching at application site
• Dryness or flaking of the skin
• Acne or folliculitis development

Serious or Rare Side Effects

• Skin atrophy or thinning with prolonged use
• Hypothalamic‑pituitary‑adrenal axis suppression
• Severe allergic reactions such as angioedema or anaphylaxis

• When prescribing or using Mometasone Furoate, several precautions should be observed to minimize risk.
• Apply to affected area only: limit use to diagnosed skin lesions.
• Avoid use on broken or infected skin: may increase systemic absorption.
• Do not use with occlusive dressings: can enhance drug penetration and side effects.
• Limit duration of therapy: follow physician guidance to prevent skin atrophy.
• Store at room temperature: keep in original container, protect from moisture and light.

Mometasone Furoate can interact with other medications, affecting its safety or efficacy.

Major Interactions (Avoid)

• Systemic corticosteroids: additive systemic glucocorticoid effects may cause adrenal suppression.
• Potent CYP3A4 inhibitors (e.g., ketoconazole): may increase local drug levels and risk of side effects.
• Live vaccines: topical steroid may reduce local immune response, potentially compromising vaccine efficacy.

Moderate Interactions (Monitor Closely)

• Topical antibiotics (e.g., mupirocin): increased risk of skin irritation.
• Phototherapy (UVB): may enhance photosensitivity and skin damage.
• Other topical steroids: cumulative potency may raise risk of skin atrophy.